Table 9 Effect of Oxaliplatin, free CDA and CDA-Dextran conjugates on hematological parameters (Hemoglobin level, RBC, WBC cells count) All values are presented as mean ± SEM. Statistical analysis was performed by one-way ANOVA (F-test). Statistical significance was defined as a p-value ≤0.05 indicating significant difference. a EAC control group versus negative control group. b Treated groups versus EAC positive control group
Parameters | Negative control | Positive control (EAC bearing) without any treatments | EAC + Oxaliplatin | EAC + Free CDA | EAC + Dextran-CDA |
|---|---|---|---|---|---|
Hemoglobin (g/dl) | 13.27 ± 1.90 | 5.93 ± 1.54* a | 9.38 ± 1.6* b | 8.53 ± 1.81* b | 10.81 ± 1.5* b |
RBC (million/m3) | 8.90 ± 0.99 | 5.51 ± 0.22* a | 7.22 ± 0.27* b | 6.65 ± 0.25* b | 7.60 ± 0.26* b |
WBC (million/mm3) | 9.03 ± 0.19 | 21.75 ± 0.38* a | 10.84 ± 0.26* b | 14.02 ± 0.38* b | 10.02 ± 0.34* b |
lymphocytes | 71.18 ± 0.49 | 36.67 ± 0.60* a | 57.67 ± 0.49* b | 54.17 ± 0.70* b | 61.50 ± 0.67* b |