Fig. 7

Histopathological sections of liver tissues from each mice group. A, Negative control group, showing the normal histological structure of the liver including central vein (CV), hepatocytes (H), blood sinusoids (BS), and lymphocytic infiltration (LI). B, positive control group, showing disorganized liver parenchyma including central vein highly congested with blood, extravasated hemorrhage, hepatocytes (H) with extensive cytoplasmic vacuolization for necrosis (N), dilated and congested blood sinusoids (BS), intensive lymphocytic infiltration (LI) surrounding destructed bile ductules (BD). C, Oxaliplatin treated mice, showing organized hepatocytes (H), with necrotic (N) regions, but a central vein (CV) still congested with few damaged erythrocytes, D, free CDA showing well organized hepatocytes (H) with vesicular nuclei, congested central vein (CV) with few damaged erythrocytes. E, CDA-Dextran conjugates showing well-organized hepatic parenchyma in hepatic strands including hepatocytes (H), still necrotic a clear central vein (CV) with intact body wall, Blood sinusoids (BS) appeared nearly similar to the control