Fig. 5

The antiproliferative activity of free and CDA-Dextran conjugates mediating the prodrug 5-FC towards the cell lines OEC, MDA-MB, HepG-2, and PC-3. Different concentrations of the prodrug 5-FC (0, 100, 200, and 300 ng/ml) were amended to the wells of the microtiter plate, then the free and CDA-dextran at 100 μmol/mg/min (A) and at 200 μmol/mg/min (B) were added, and the cellular viability was determined by MTT assay. The viability of the MDA-MB, HepG-2, and PC-3, in addition to the normal cells OEC was determined. The significant *p-values < 0.1, and highly significant **p-values < 0.01, were calculated by Student’s t-test to the activity of the free CDA and Dextran-CDA conjugates towards the lines “OEC, MDA-MB, HepG-2, and PC-3”