Skip to main content

Table 1 Main genes affected by gdpS mutation in S. epidermidis (RNA-seq)

From: Mutation of gdpS gene induces a viable but non-culturable state in Staphylococcus epidermidis and changes in the global transcriptional profile

locus_tag

Gene symbol

Gene Product

logFC

(ΔgdpS /WT)

Biological functions/pathways

SERP_RS02180

gdpS

GGDEF domain-containing protein

-10.65

 

SERP_RS05895

 

hypothetical protein

1.01

 

SERP_RS06915

 

glutamate ABC transporter permease

1.04

 

SERP_RS08330

ilvC

ketol-acid reductoisomerase

1.34

Valine, leucine and isoleucine biosynthesis

SERP_RS08335

leuA

2-isopropylmalate synthase

1.03

SERP_RS08340

leuB

3-isopropylmalate dehydrogenase

1.1

SERP_RS09425

ssaA

secretory antigen precursor SsaA

-1.02

 

SERP_RS09875

narT

NarK/NasA family nitrate transporter

1.81

Nitrogen metabolism

SERP_RS09885

nreB

sensor histidine kinase

1.28

SERP_RS09890

nreA

nitrate respiration regulation accessory nitrate

sensor NreA

1.02

SERP_RS09895

narI

respiratory nitrate reductase subunit gamma

1.24

SERP_RS09900

narJ

respiratory nitrate reductase subunit delta

1.6

SERP_RS09905

narH

respiratory nitrate reductase subunit beta

1.59

SERP_RS09910

narG

respiratory nitrate reductase subunit alpha

1.54

SERP_RS09915

cobA

uroporphyrinogen-III C-methyltransferase

1.15

SERP_RS09920

nirD

nitrite reductase small subunit

1.26

SERP_RS09925

nirB

nitrite reductase large subunit

1.28

SERP_RS10790

betB

betaine aldehyde dehydrogenase

-1

 

SERP_RS11285

icaA

poly-beta-1,6 N-acetyl-D-glucosamine synthase

-2.33

Pathogenesis

SERP_RS11290

icaD

poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein IcaD

-2.24

SERP_RS11295

icaB

poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase

-2.19

SERP_RS11300

icaC

poly-beta-1,6-N-acetyl-D-glucosamine export protein

-1.93

SERP_RS11375

mqo

malate:quinone oxidoreductase

1.04

 

SERP_RS11730

gehD

YSIRK domain-containing triacylglycerol lipase GehD

-1.49

 

SERP_RS12370

rlmH

23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH

-1.32

 

SERP_RS01900

 

hypothetical protein

-1.16

 

SERP_RS01910

fruR2

DeoR/GlpR family DNA-binding transcription regulator

-1.08

 

SERP_RS01960

 

DM13 domain-containing protein

-1.1

 

SERP_RS02070

adhE

bifunctional acetaldehyde-CoA/alcohol dehydrogenase

-1.5

 

SERP_RS02810

argH

argininosuccinate lyase

1.23

Arginine biosynthesis

SERP_RS02815

argG

argininosuccinate synthase

1.92

SERP_RS02920

oppB

ABC transporter permease

1.02

ABC transporter

SERP_RS02925

oppC

ABC transporter permease

1.2

SERP_RS02930

oppD

ABC transporter ATP-binding protein

1.21

SERP_RS03730

psmβ1a

beta-class phenol-soluble modulin

1.44

Pathogenesis

SERP_RS03740

psmβ3

beta-class phenol-soluble modulin

1.3

SERP_RS03870

pyrP

uracil permease

1.23

 

SERP_RS03895

pyrF

orotidine-5'-phosphate decarboxylase

1.17

Pyrimidine metabolism

SERP_RS03900

pyrE

orotate phosphoribosyltransferase

1.22

 

SERP_RS04360

glpF

glycerol uptake facilitator protein

3.32

Glycerophospholipid metabolism

SERP_RS04365

glpK

glycerol kinase

2.16

SERP_RS04370

glpD

aerobic glycerol-3-phosphate dehydrogenase

4.66

SERP_RS04825

lysC

aspartate kinase

1.47

Lysine biosynthesis

SERP_RS04830

asd

aspartate-semialdehyde dehydrogenase

1.26

SERP_RS04835

dapA

4-hydroxy-tetrahydrodipicolinate synthase

1.17

SERP_RS04840

dapB

4-hydroxy-tetrahydrodipicolinate reductase

1.07