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Fig. 8 | BMC Microbiology

Fig. 8

From: Multiomics analyses reveals Anaplasma phagocytophilum Ats-1 induces anti-apoptosis and energy metabolism by upregulating the respiratory chain-mPTP axis in eukaryotic mitochondria

Fig. 8

Ats-1 enhanced the respiratory activity and proliferation of HEK293T cells. (A) Analysis of qRT-PCR results. NDUFB5, COX6C, SLC25A4, and SLC25A5 were up-regulated after transfection with Ats-1 at the mRNA level, while SDHC and NDUFS7 were down-regulated. (B) ATP measurements in HEK293T cells. ATP levels significantly increased in cells after transfection with Ats-1 compared to transfection with an empty vector. (C) Cellular proliferation tests. Based on the CCK-8 method, the OD values were positively correlated with the number of living cells, thereby indirectly reflecting the proliferation of cells. Cellular proliferation was enhanced after transfection with Ats-1 compared to transfection with an empty vector. The results represent the results from three independent experiments. Data are shown as means ± SD from three independent tests. Ns: no significant difference, *: p < 0.05, **: p < 0.01, ***: p < 0.001, ****: p < 0.0001.

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BMC Microbiology

ISSN: 1471-2180

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