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Table 5 Mutations found in the hotspot parE of S. Typhi

From: Hotspots sequences of gyrA, gyrB, parC, and parE genes encoded for fluoroquinolones resistance from local Salmonella Typhi strains in Jakarta

Mutation

Susceptibility Profile

Study

Ala364Val

OFX (R), CIP (R), NAL (R)

[27]a

Asp420Asn

CIP (S), NAL (R)

[31]b

Tyr434Ser

CIP (I), NAL (R)

[19] c

Ile444Ser

CIP (I), NAL (R)

[19] c,d

Ser493Phe

NAL (I), CIP (S)

[18]e

  1. aDouble mutations: gyrA Ser83Phe and parE Ala364Val; gyrA Ser83Tyr and parE Ala364Val; gyrA Asp87Asn and parE Ala364Val
  2. bDouble mutations: gyrA Ser83Phe and parE Asp420Asn
  3. cFour mutations: gyrA Ser83Phe, gyrA Glu133Gly, parE Ile444Ser, and parE Tyr434Ser
  4. dThree mutations: gyrA Ser83Phe, gyrA Glu133Gly, and parE Ile444Ser
  5. eDouble mutations in one isolate: gyrA Ser83Tyr and parE Ser493Phe
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BMC Microbiology

ISSN: 1471-2180

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