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Fig. 4 | BMC Microbiology

Fig. 4

From: Surface layer protein A from hypervirulent Clostridioides difficile ribotypes induce significant changes in the gene expression of tight junctions and inflammatory response in human intestinal epithelial cells

Fig. 4

The effects of SlpA extracted from C. difficile clinical strains on human colon carcinoma cell line HT-29. SlpA binds to its receptor, TLR-4, results in increased expression and production of proinflammatory cytokines such as TNF-α, IL-6 and IL-8 in intestinal epithelial cells. SlpA from certain C. difficile RTs (SlpA purified from RT126) could significantly enhance IL-1β production in the gut, possibly through the bioprocessing of pro-IL-1β to its active form IL-1β following activation of the inflammasome pathway. Additionally, SlpA could distrupt tight junction and subsequently may increase intestinal permeability. RT, ribotype; TLR-4, toll-like receptor-4

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BMC Microbiology

ISSN: 1471-2180

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