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Table 2 Minimum biofilm inhibitory concentrations (MBICs) of antibiotics against S. aureus

From: Zinc oxide nanoparticles reduce biofilm formation, synergize antibiotics action and attenuate Staphylococcus aureus virulence in host; an important message to clinicians

Isolate NO

Gentamicin (µg/mL)

Ciprofloxacin

(µg/mL)

Clindamycin

(µg/mL)

Chloramphenicol

(µg/mL)

Cefotaxime

(µg/mL)

Azithromycin

(µg/mL)

MIC

MBIC

MIC

MBIC

MIC

MBIC

MIC

MBIC

MIC

MBIC

MIC

MBIC

S. aureus ATCC 6538

4

32

2

64

0.03

32

4

8

128

8192

0.5

512

1B

128

512

2

64

0.06

2

16

128

16

64

4

256

2B

32

64

0.125

64

< .003

16

4

16

0.125

4

0.25

128

24B

1024

˃4096

128

2048

512

2048

128

1024

2048

8192

> 1024

˃8192

38B

1024

4096

64

256

8

64

64

128

1024

4096

> 1024

˃8192

41B

2

16

1

128

< .003

32

4

16

0.125

128

1

256

42B

64

1024

0.25

128

0.25

32

0.5

256

0.125

64

1

128

44B

8

32

1

32

0.25

32

4

8

64

512

1

256

48U

4

16

8

64

0.03

32

4

8

256

4096

64

8192

55EY

64

256

0.25

64

0.015

32

4

16

0.125

8

0.5

256

62EN

8

16

16

64

0.03

2

8

32

32

128

32

8192

63EN

8

16

16

256

0.5

1

32

128

128

2048

32

256

68EA

0.5

256

32

128

< .003

64

8

64

0.5

2048

0.5

1024

82W

2

8

0.5

128

0.015

32

8

16

16

64

0.5

256

83W

1

16

0.25

64

0.06

32

8

32

0.5

256

2

256

91W

8

32

1024

4096

256

1024

16

32

1024

2048

512

8192

97W

1024

4096

32

1024

256

1024

64

128

1024

4096

> 1024

8192

99W

256

8192

64

512

4

4096

128

512

1024

4096

32

˃8192

101W

1024

˃4096

64

1024

1024

2048

64

1024

1024

8192

> 1024

8192

  1. B Burn, U Urine, EY Eye, EN Endotracheal aspirate, EA Ear, W Wound