Table 4 Stress response defense virulence in B. cereus s.s. 3A ES

Toxins and superantigens

Pore-forming cytolytic toxins

1

1

active

Stress Response: Osmotic stress

Choline uptake and conversion to betaine clusters

8

5

active

Stress Response: Osmotic stress

Osmoregulation

2

2

active

Stress Response: Heat/cold shock

Heat shock dnaK gene cluster extended

16

16

active

Stress Response: Heat/cold shock

Cold shock proteins of CSP family

6

2

active

Stress Response: Electrophile toxicity

Bacillithiol synthesis

4

3

active

Stress Response

Cluster containing Glutathione synthetase

2

2

likely

Stress Response

Glutathione: Non-redox reactions

4

2

likely

Stress Response

CoA disulfide thiol-disulfide redox system

1

2

active

Stress Response

Protection from Reactive Oxygen Species

9

7

active

Stress Response

Universal stress protein family

2

1

active

Stress Response

Repair of Iron Centers

1

1

active

Stress Response

Glutathione: Redox cycle

1

1

active

Stress Response

Stress proteins YciF, YciE

1

1

active

Resistance to antibiotics and toxic compounds

Aminoglycoside modifying enzymes: O-nucleotidyltransferases

1

1

active

Resistance to antibiotics and toxic compounds

Fosfomycin resistance

1

1

active

Resistance to antibiotics and toxic compounds

Resistance to Daptomycin

14

7

active

Resistance to antibiotics and toxic compounds

Resistance to Vancomycin and Teicoplanin

7

3

likely

Resistance to antibiotics and toxic compounds

Beta-lactamases Ambler class A

2

1

active

Resistance to antibiotics and toxic compounds

Antibiotic targets in protein synthesis

9

8

active

Resistance to antibiotics and toxic compounds

Antibiotic targets in metabolic pathways

7

5

active

Resistance to antibiotics and toxic compounds

Antibiotic targets in DNA processing

4

4

active

Resistance to antibiotics and toxic compounds

VraTSR and LiaFSR three-component regulatory systems

5

5

active

Resistance to antibiotics and toxic compounds

Copper homeostasis: copper tolerance

1

1

active

Resistance to antibiotics and toxic compounds

Fusidic acid resistance

2

2

likely

Resistance to antibiotics and toxic compounds

Macrolides, lincosamides, streptogramins, ketolides, oxazolidinones (MLSKO) resistance: enzymatic degradation

1

1

active

Resistance to antibiotics and toxic compounds

Bacitracin resistance

3

3

active

Resistance to antibiotics and toxic compounds

Antibiotic targets in cell wall biosynthesis

6

3

active

Resistance to antibiotics and toxic compounds

Vancomycin resistance, D-Ala-D-Ala dipeptidases and carboxypeptidases

1

1

active

Resistance to antibiotics and toxic compounds

Arsenic resistance

7

5

active

Resistance to antibiotics and toxic compounds

Antibiotic targets in transcription

3

3

active

Resistance to antibiotics and toxic compounds

Aminoglycoside modifying enzymes: N-acetyltransferases

1

1

likely

Resistance to antibiotics and toxic compounds

Beta-lactamases Ambler class B

1

1

active

Resistance to antibiotics and toxic compounds

Resistance to Triclosan

1

1

active

Resistance to antibiotics and toxic compounds

Resistance to chromium compounds

1

1

active

Resistance to antibiotics and toxic compounds

Mupirocin resistance

2

1

likely

Resistance to antibiotics and toxic compounds

Chloramphenicol resistance

1

1

active

Resistance to antibiotics and toxic compounds

Tetracycline resistance, all mechanisms

2

2

active

Resistance to antibiotics and toxic compounds

Macrolides, lincosamides, streptogramins, ketolides, oxazolidinones (MLSKO) resistance: ribosomal protection

1

1

active

Invasion and intracellular resistance

Listeria surface proteins: Internalin-like proteins

3

1

active

Host–pathogen interactions

Hydrolysis of sphingomyelin

2

2

active

Hfl operon

5

5

active