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Fig. 4 | BMC Microbiology

Fig. 4

From: Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro

Fig. 4

Time-dependent killing of A. baumannii by the combination of minocycline and metformin. MIC of minocycline and 0.25 × MIC of metformin of strains were selected as treatment concentrations. A minocycline (MIN, 4 µg/mL) or metformin (MET, 5 mg/mL) alone or in combination (MIN + MET, 4 µg m/L + 5 mg/mL). B minocycline (MIN, 8 µg/mL) or metformin (MET, 5 mg/mL) alone or in combination (MIN + MET, 8 µg m/L + 5 mg/mL). C minocycline (MIN, 32 µg/mL) or metformin (MET, 10 mg/mL) alone or in combination (MIN + MET, 32 µg/mL + 10 mg/mL). Data are representative of three biological replicates and presented as mean ± SD

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