Skip to main content
Fig. 2 | BMC Microbiology

Fig. 2

From: Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro

Fig. 2

Checkerboard assays of metformin with different classes of antibiotics against A. Baumannii A1 strain. The primary screening indicated that metformin had a synergistic activity with minocycline against A. Baumannii A1 strain. A Metformin in combination with kanamycin, FICI ≥ 2; B Metformin in combination with tetracycline, FICI = 0.75; C Metformin in combination with tigecycline, FICI = 0.5; D Metformin in combination with vancomycin FICI = 0.75; E Metformin in combination with ampicillin, FICI ≥ 2; F Metformin in combination with minocycline, FICI = 0.1875; G Metformin in combination with erythromycin, FICI = 0.75; H Metformin in combination with ciprofloxacin, FICI = 1; I Metformin in combination with imipenem, FICI ≥ 2. The synergy is defined as FICI ≤ 0.5; irrelevance is defined as 0.5 < FICI ≤ 4; and antagonism is defined as FICI > 4

Back to article page

BMC Microbiology

ISSN: 1471-2180

Contact us