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Fig. 1 | BMC Microbiology

Fig. 1

From: Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro

Fig. 1

Diagrammatic representation depicting hypothetical view of the metformin and minocycline combination in culminating lactic acidosis. Metformin can inhibit liver mitochondrial respiration, thus increasing plasma lactate levels. Metformin-associated lactic acidosis (MALA) can be caused by elevated plasma metformin concentrations and disrupted lactate production or clearance. A decrease antihyperglycemic effect of metformin maybe observed after concomitant administration with minocycline because of gut microbiome change, and may cause a decrease production of lactate. This hypothetical need more research to prove

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BMC Microbiology

ISSN: 1471-2180

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