Fig. 2

Macrophage migration in collagen gels of different concentrations: 2.5 mg/mL (blue), 4 mg/mL (orange) and 6 mg/mL (yellow). A Representation of the relative trajectories of macrophages, each line being the individual trajectory of a cell. B Directionality of migration considering the length of the radius as the number of cells that migrated in that direction and normalized by the total number of cells per condition. C Mean squared displacement (MSD) of the tracked trajectories, where D is the diffusive coefficient and α is the power law fitting coefficient (MSD(t) = γ.t^α). D Mean and effective velocity, where mean velocity is the total distance migrated divided by the time spent, and effective velocity is the distance between the starting and final point of the cell divided by the time spent. Asterisks indicate significant differences as follows: **p < 0.01, ***p < 0.005. n (devices) = 9 (2.5 mg/mL gels), 3 (4 mg/mL gels) and 3 (6 mg/mL gels), with an average of 25 cells per device