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Table 1 Longevity of different C. elegans strains upon C. neoformans 32045 and C. gattii 56992 infections

From: Caenorhabditis elegans DAF-16 regulates lifespan and immune responses to Cryptococcus neoformans and Cryptococcus gattii infections

Strain

 

Mean

SD

SE

Median

Max

No.

P-value

%

 

 + E. coli OP50

9.15

1.75

0.15

9.00

12.00

141

   

Wild-type

 + C. neoformans

3.04

1.57

0.13

3.00

9.00

138

 < 0.0001

****

-66.78%

 

 + C. gattii###

4.10

1.73

0.15

4.00

9.00

139

 < 0.0001

****

-55.19%

 

 + E. coli OP50

5.79

1.99

0.17

6.00

9.00

143

   

sek-1

 + C. neoformans

2.63

1.21

0.11

2.50

6.00

138

 < 0.0001

****

-54.58%

 

 + C. gattiins

2.36

1.12

0.10

2.00

5.00

139

 < 0.0001

****

-59.24%

 

 + E. coli OP50

16.89

6.90

0.59

21.00

27.00

138

   

age-1

 + C. neoformans

5.50

1.78

0.15

6.00

10.00

141

 < 0.0001

****

-67.44%

 

 + C. gattii#

6.80

2.21

0.19

7.00

11.00

139

 < 0.0001

****

-59.74%

 

 + E. coli OP50

3.97

1.76

0.15

4.00

7.00

144

   

daf-16

 + C. neoformans

1.62

1.06

0.09

1.00

5.00

138

 < 0.0001

****

-59.19%

 

 + C. gattiins

1.51

0.95

0.08

1.00

5.00

136

 < 0.0001

****

-61.96%

 

 + E. coli OP50

7.64

2.33

0.20

8.00

11.00

137

   

jnk-1

 + C. neoformans

2.64

1.39

0.12

3.00

6.00

139

 < 0.0001

****

-65.45%

 

 + C. gattiins

2.50

1.38

0.12

3.00

6.00

141

 < 0.0001

****

-67.28%

 

 + E. coli OP50

6.85

1.93

0.17

7.00

10.00

137

   

sir-2.1

 + C. neoformans

2.71

1.16

0.10

3.00

5.00

139

 < 0.0001

****

-60.44%

 

 + C. gattiins

2.53

1.18

0.10

3.00

5.00

140

 < 0.0001

****

-63.07%

 

 + E. coli OP50

5.57

1.71

0.14

6.00

8.00

140

   

osr-1

 + C. neoformans

2.77

1.28

0.11

3.00

5.00

136

 < 0.0001

****

-50.27%

 

 + C. gattiins

2.66

1.34

0.11

3.00

5.00

138

 < 0.0001

****

-52.24%

  1. Note: Means, standard deviation (SD), standard error (SE), median, and maximum of lifespan were shown in days. Total worms (No.) were represented as summation of worms in triplicates (with censored worms excluded). The lifespan data were analyzed using the log‐rank test and P‐values for each individual experiment were shown when compared to corresponding control as *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; NS, not significant (P > 0.05). Comparison of statistically significant differences between C. neoformans and C. gattii infected groups was indicated as #P < 0.05; ##P < 0.01; ###P < 0.001; ####P < 0.0001; NS, not significant (P > 0.05). Results presented in Fig. 1B-H