Table 7 Loci and types of mutations conferring aminoglycosides and capreomycin resistance in MTB clinical isolates belonging to different genotypes
Loci and types of mutations | Number of MTB isolates with eis and rrs mutations from HIV – patients | Number of MTB isolates with eis and rrs mutations from HIV+ patients | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
BEIJING | LAM | Ural | TOTAL | BEIJING | Ural | TOTAL | |||||
TOTAL | B0 / W148 | Other | TOTAL | B0 / W148 | Other | ||||||
eis g10a | 21 | 7 | 14 | 3 | 1 | 25 | 6 | 4 | 2 | 1 | 7 |
eis g10c | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
eis c12t | 4 | 2 | 2 | 4 | 1 | 9 | 1 | 1 | 0 | 1 | 2 |
eis a13g | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
eis c14t | 12 | 4 | 8 | 1 | 1 | 14 | 4 | 2 | 2 | 0 | 4 |
eis g37t | 15 | 2 | 13 | 7 | 0 | 22 | 2 | 0 | 2 | 0 | 2 |
Total eis | 52 | 15 | 37 | 15 | 3 | 70 | 13 | 7 | 6 | 2 | 15 |
rrs a1401g | 26 | 9 | 17 | 0 | 0 | 26 | 8 | 0 | 8 | 0 | 8 |
rrs c1402a | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
rrs c1402t | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
rrs g1484t | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 |
Total rrs | 26 | 9 | 17 | 1 | 0 | 27 | 9 | 0 | 9 | 0 | 9 |