Table 6 Loci and types of mutations conferring FQ resistance in MTB clinical isolates belonging to different genotypes
Loci and types of mutations | Number of MTB isolates with gyrA and gyrB mutations from HIV - patients | Number of MTB isolates with gyrA and gyrB mutations from HIV+ patients | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
BEIJING | LAM | Ural, X1 | TOTAL | BEIJING | Ural | TOTAL | |||||
TOTAL | B0 / W148 | Other | TOTAL | B0 / W148 | Other | ||||||
gyrA70 His70Arg | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
gyrA74 Ala74Ser | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
gyrA80Thr80Ala | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 |
gyrA 88 Gly88Ala; Gly88Cys | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
gyrA 90-91 Ala90Val-Ser91Pro | 6 | 0 | 6 | 0 | 1 | 7 | 5 | 4 | 1 | 1 | 6 |
gyrA 90-91 Ala90Gly-Ser91Pro | 8 | 8 | 0 | 0 | 0 | 8 | 0 | 0 | 0 | 0 | 0 |
gyrA 94-95 Asp94Ala -Ser95Thr | 11 | 7 | 4 | 1 | 0 | 12 | 2 | 2 | 0 | 1 | 3 |
gyrA 94-95 Asp94Gly- Ser95Thr | 16 | 0 | 16 | 2 | 0 | 18 | 8 | 6 | 2 | 0 | 8 |
gyrA 94-95 Asp94His- Ser95Thr | 2 | 0 | 2 | 2 | 0 | 4 | 0 | 0 | 0 | 0 | 0 |
gyrA 94-95 Asp94Asn- Ser95Thr | 9 | 4 | 5 | 0 | 1 | 10 | 4 | 2 | 2 | 1 | 5 |
gyrA 94-95 Asp94Val- Ser95Thr | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
gyrA 94-95 Asp94Tyr- Ser95Thr | 1 | 0 | 1 | 0 | 1 | 2 | 1 | 0 | 1 | 0 | 1 |
gyrA 102 Pro102His | 3 | 2 | 1 | 2 | 0 | 5 | 1 | 0 | 1 | 0 | 0 |
Total gyrA | 57 | 21 | 36 | 7 | 3 | 67 | 22 | 14 | 8 | 3 | 25 |
gyrB 485 Arg485His; Arg485Leu | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
gyrB 486 Ser486Phe | 2 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
gyrB 500 Asp500Asn | 2 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
gyrB 500 Asp500His; Asp500Ala | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
gyrB 509 Gly509Cys; Gly509Ala | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
gyrB 525 Ile525Leu | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
gyrB 533 Asp533Ala | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
gyrB 538 Asn538 Asp | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
gyrB 538 Asn538Tyr; Asn538Lys; Asn538Thr | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
gyrB 539 Thr539 Ile | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
gyrB 539 Thr539 Asn | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
gyrB 539 Thr539Pro | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
gyrB 540 Glu540Asp | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
gyrB 543 Ala543Thr | 2 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
gyrB 543 Ala543Val | 2 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
Total gyrB | 10 | 2 | 8 | 0 | 1 | 11 | 0 | 0 | 0 | 0 | 0 |