Table 5 Loci and types of mutations conferring EMB resistance in MTB clinical isolates belonging to different genotypes
Loci and types of mutations | Number of MTB isolates with embB mutations from HIV - patients | Number of MTB isolates with embB mutations from HIV+ patients | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
BEIJING | LAM | Ural, T1, T3, Haarlem | TOTAL | BEIJING | LAM, Ural | TOTAL | |||||
TOTAL | B0 / W148 | Other | TOTAL | B0 / W148 | Other | ||||||
embB 296 Asn296His | 15 | 5 | 10 | 2 | 3 | 20 | 9 | 9 | 0 | 0 | 9 |
embB297 Ser297Ala | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 |
embB306 Met306Leu | 21 | 8 | 13 | 4 | 3 | 28 | 10 | 4 | 6 | 0 | 10 |
embB306, Met306Val | 35 | 11 | 24 | 8 | 2 | 45 | 27 | 12 | 15 | 3 | 30 |
embB309 Val309Phe | 5 | 1 | 4 | 2 | 3 | 10 | 0 | 0 | 0 | 0 | 0 |
embB313 Ala313Val | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 3 | 0 | 3 |
embB319 Tyr319Cys | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
embB319 Tyr319Ser | 2 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
embB319 Tyr319Asp | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
embB328 Asp328Tyr;Asp328Gly | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
embB354 Asp354Ala | 20 | 3 | 17 | 2 | 1 | 23 | 5 | 0 | 5 | 0 | 5 |
embB378 Glu378Ala | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 2 |
embB406 Gly406Ala | 46 | 43 | 3 | 0 | 0 | 46 | 2 | 0 | 2 | 0 | 2 |
embB406 Gly406Asp | 3 | 3 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 |
embB406 Gly406Ser | 1 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 2 | 0 | 2 |
embB406 Gly406Cys | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
embB497 Gln497Lys | 5 | 5 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | 0 | 0 |
embB497 Gln497Pro | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
embB497 Gln497Arg | 12 | 0 | 12 | 0 | 0 | 12 | 2 | 0 | 2 | 0 | 2 |
 TOTAL | 165 | 80 | 85 | 19 | 14 | 198 | 63 | 26 | 37 | 3 | 66 |