Table 3 Loci and types of mutations conferring INH resistance in MTB clinical isolates belonging to different genotypes
 Loci and types of mutations | Number of MTB isolates with mutations conferring INH resistance from HIV - patients | Number of MTB isolates with mutations conferring INH resistance from HIV+ patients | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
BEIJING | LAM | Ural, T1 | TOTAL | BEIJING | LAM, Ural | TOTAL | |||||
TOTAL Beijing | B0 / W148 Beijing | Other Beijing | TOTAL Beijing | B0 / W148 Beijing | Other Beijing | ||||||
katG 315-Ser315Thr | 166 | 64 | 102 | 27 | 7 | 200 | 73 | 28 | 45 | 0 | 73 |
katG 315- Ser315Arg | 2 | 0 | 2 | 0 | 0 | 2 | 1 | 0 | 1 | 0 | 1 |
katG 315-Ser315Gly | 2 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
katG 315 Ser315Ile; Ser315Asn | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
katG 328-Trp328Cys | 2 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
katG 328 Trp328Gly; Trp328Leu | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
katG 335-Iley335Val | 5 | 0 | 5 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 |
Total katG | 176 | 64 | 113 | 27 | 7 | 211 | 74 | 28 | 46 | 0 | 74 |
inhA t8a | 8 | 0 | 8 | 0 | 0 | 8 | 0 | 0 | 0 | 0 | 0 |
inhA t8g | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
inhA t15a | 23 | 3 | 20 | 11 | 1 | 35 | 2 | 1 | 1 | 3 | 5 |
inhA a16g | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
inhA t24a | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Total INH A | 31 | 3 | 28 | 11 | 1 | 43 | 2 | 1 | 1 | 3 | 5 |