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Table 3 The list of the properties of key nodes based on the PPI network analysis

From: Quorum quenching of Streptococcus mutans via the nano-quercetin-based antimicrobial photodynamic therapy as a potential target for cariogenic biofilm

Nodes Predicted functional partners Neighborhood Gene Fusion Co-occurrence Co-expression Experiments Databases Textmining Score
comD Two-component system, lyttr family, sensor histidine kinase agrc; Putative histidine kinase of the competence regulon        * 0.750
comE Putative response regulator of the competence regulon, come; Response regulator of the competence regulon ComE        * 0.750
gtfB Glucosyltransferase-i; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris        * 0.711
glrA ABC-2 type transport system ATP-binding protein        * 0.585
gtfC Glucosyltransferase-si; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris        * 0.516
SMU_1914c Hypothetical protein; Uncharacterized protein *        0.442
gbpB Peptidoglycan dl-endopeptidase cwlo; Putative secreted antigen GbpB/SagA putative peptidoglycan hydrolase        * 0.429
SMU_286 Atp-binding cassette, subfamily c, bacteriocin exporter        * 0.429
ciaH Two-component system, ompr family, sensor histidine kinase ciah; Putative histidine kinase sensor CiaH        * 0.428
luxS Putative autoinducer-2 production protein luxs; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD)        * 0.428