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Table 2 MIC of the N6 and PEGylated N6 analogues

From: C-terminal mini-PEGylation of a marine peptide N6 had potent antibacterial and anti-inflammatory properties against Escherichia coli and Salmonella strains in vitro and in vivo

Species and strains MIC
N6 N6-COOH-miniPEG N6-NH2-miniPEG N6-NH2-PEG6 N6-NH2-PEG12 N6-NH2-PEG24 N6-Cys7-miniPEG N6-Cys16-miniPEG
μg/mL μM μg/mL μM μg/mL μM μg/mL μM μg/mL μM μg/mL μM μg/mL μM μg/mL μM
Gram-negative bacteria
  E. coli CVCC195 4 1.61 8 3.05 16 6.1 16 5.69 32 10.4 128 35.51  > 128  > 48.84 128 48.84
  E. coli CVCC1515 4 1.61 8 3.05 16 6.1 32 11.38 64 20.81  > 128  > 35.51  > 128  > 48.84 128 48.84
  E. coli CVCC25922 4 1.61 4 1.53 8 3.05 8 2.85 16 5.2 128 35.51  > 128  > 48.84 128 48.84
  E. coli ATCCO157 4 1.61 8 3.05 16 6.10 32 11.38 32 10.4  > 128  > 35.51  > 128  > 48.84  > 128  > 48.84
  S. typhimurium ATCC14028 8 3.23 8 3.05 16 6.10 32 11.38 64 20.8  > 128  > 35.51  > 128  > 48.84  > 128  > 48.84
  S. pullorum CVCC1802 4 1.61 8 3.05 16 6.10 16 5.69 32 10.4 128 35.51  > 128  > 48.84 128 48.84
  S. pullorum CVCC1789 8 3.23 16 6.1 16 6.10 32 11.38 64 20.8  > 128  > 35.51  > 128  > 48.84  > 128  > 48.84
  S. enteritidis CVCC3377 8 3.23 16 6.1 16 6.10 32 11.38 32 10.4 128 35.51  > 128  > 48.84 128 48.84
  S. pullorum CVCC533 8 3.23 16 6.1 32 12.21 32 11.38 64 20.81  > 128  > 35.51  > 128  > 48.84  > 128  > 48.84
  P. aeruginosa CICC21630 32 12.91 64 24.42 64 24.42 128 45.53  > 128  > 41.62  > 128  > 35.51  > 128  > 48.84  > 128  > 48.84
Gram-positive bacteria
  S. aureus ATCC43300 64 25.83 64 24.42 128 48.84  > 128  > 45.53  > 128  > 41.62  > 128  > 35.51  > 128  > 48.84  > 128  > 48.84
  S. aureus ATCC546 64 25.83 128 48.84 128 48.84  > 128  > 45.53  > 128  > 41.62  > 128  > 35.51  > 128  > 48.84  > 128  > 48.84
  S. aureus ATCC25923 64 25.83 128 48.84  > 128  > 48.84  > 128  > 45.53  > 128  > 41.62  > 128  > 35.51  > 128  > 48.84  > 128  > 48.84
  S. hyicus NCTC10350  > 128  > 51.66  > 128  > 48.84  > 128  > 48.84  > 128  > 45.53  > 128  > 41.62  > 128  > 35.51  > 128  > 48.84  > 128  > 48.84
  S. hyicus 437-2a 128 51.66  > 128 48.84  > 128  > 48.84  > 128  > 45.53  > 128  > 41.62  > 128  > 35.51  > 128  > 48.84  > 128  > 48.84
Fungus
  C. albicans CMCC98001  > 128  > 51.66  > 128  > 48.84  > 128  > 48.84  > 128  > 45.53  > 128  > 41.62  > 128  > 35.51  > 128  > 48.84  > 128  > 48.84
  1. aClinical isolated strain of Tianjin pig farm. CVCC China Veterinary Culture Collection Center, ATCC American Type Culture Collection, CICC China Center of Industrial Culture Collection, NCTC National Collection of Type Cultures, CMCC National Center for Medical Culture Collection