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Table 2 MIC of the N6 and PEGylated N6 analogues

From: C-terminal mini-PEGylation of a marine peptide N6 had potent antibacterial and anti-inflammatory properties against Escherichia coli and Salmonella strains in vitro and in vivo

Species and strains

MIC

N6

N6-COOH-miniPEG

N6-NH2-miniPEG

N6-NH2-PEG6

N6-NH2-PEG12

N6-NH2-PEG24

N6-Cys7-miniPEG

N6-Cys16-miniPEG

μg/mL

μM

μg/mL

μM

μg/mL

μM

μg/mL

μM

μg/mL

μM

μg/mL

μM

μg/mL

μM

μg/mL

μM

Gram-negative bacteria

  E. coli CVCC195

4

1.61

8

3.05

16

6.1

16

5.69

32

10.4

128

35.51

 > 128

 > 48.84

128

48.84

  E. coli CVCC1515

4

1.61

8

3.05

16

6.1

32

11.38

64

20.81

 > 128

 > 35.51

 > 128

 > 48.84

128

48.84

  E. coli CVCC25922

4

1.61

4

1.53

8

3.05

8

2.85

16

5.2

128

35.51

 > 128

 > 48.84

128

48.84

  E. coli ATCCO157

4

1.61

8

3.05

16

6.10

32

11.38

32

10.4

 > 128

 > 35.51

 > 128

 > 48.84

 > 128

 > 48.84

  S. typhimurium ATCC14028

8

3.23

8

3.05

16

6.10

32

11.38

64

20.8

 > 128

 > 35.51

 > 128

 > 48.84

 > 128

 > 48.84

  S. pullorum CVCC1802

4

1.61

8

3.05

16

6.10

16

5.69

32

10.4

128

35.51

 > 128

 > 48.84

128

48.84

  S. pullorum CVCC1789

8

3.23

16

6.1

16

6.10

32

11.38

64

20.8

 > 128

 > 35.51

 > 128

 > 48.84

 > 128

 > 48.84

  S. enteritidis CVCC3377

8

3.23

16

6.1

16

6.10

32

11.38

32

10.4

128

35.51

 > 128

 > 48.84

128

48.84

  S. pullorum CVCC533

8

3.23

16

6.1

32

12.21

32

11.38

64

20.81

 > 128

 > 35.51

 > 128

 > 48.84

 > 128

 > 48.84

  P. aeruginosa CICC21630

32

12.91

64

24.42

64

24.42

128

45.53

 > 128

 > 41.62

 > 128

 > 35.51

 > 128

 > 48.84

 > 128

 > 48.84

Gram-positive bacteria

  S. aureus ATCC43300

64

25.83

64

24.42

128

48.84

 > 128

 > 45.53

 > 128

 > 41.62

 > 128

 > 35.51

 > 128

 > 48.84

 > 128

 > 48.84

  S. aureus ATCC546

64

25.83

128

48.84

128

48.84

 > 128

 > 45.53

 > 128

 > 41.62

 > 128

 > 35.51

 > 128

 > 48.84

 > 128

 > 48.84

  S. aureus ATCC25923

64

25.83

128

48.84

 > 128

 > 48.84

 > 128

 > 45.53

 > 128

 > 41.62

 > 128

 > 35.51

 > 128

 > 48.84

 > 128

 > 48.84

  S. hyicus NCTC10350

 > 128

 > 51.66

 > 128

 > 48.84

 > 128

 > 48.84

 > 128

 > 45.53

 > 128

 > 41.62

 > 128

 > 35.51

 > 128

 > 48.84

 > 128

 > 48.84

  S. hyicus 437-2a

128

51.66

 > 128

48.84

 > 128

 > 48.84

 > 128

 > 45.53

 > 128

 > 41.62

 > 128

 > 35.51

 > 128

 > 48.84

 > 128

 > 48.84

Fungus

  C. albicans CMCC98001

 > 128

 > 51.66

 > 128

 > 48.84

 > 128

 > 48.84

 > 128

 > 45.53

 > 128

 > 41.62

 > 128

 > 35.51

 > 128

 > 48.84

 > 128

 > 48.84

  1. aClinical isolated strain of Tianjin pig farm. CVCC China Veterinary Culture Collection Center, ATCC American Type Culture Collection, CICC China Center of Industrial Culture Collection, NCTC National Collection of Type Cultures, CMCC National Center for Medical Culture Collection
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BMC Microbiology

ISSN: 1471-2180

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