Fig. 8

Effects of N6 and N6-COOH-miniPEG on organ injury in mice. Mice were infected intraperitoneally with E. coli CVCC195 (1 × 10⁹ CFU/mL, 200 μL) and treated with N6 (4 μmol/kg) or N6-COOH-miniPEG (4 μmol/kg). Livers, spleens, kidneys and lungs were harvested from sacrificed mice at 24 h after infection. CK group: The livers, spleens, kidneys, and lungs were normal; Infected E. coli CVCC195 group: Inflammatory lesions such as foci of hepatocellular necrosis, reactive enlargement of small splenic nodules, localized foci of interstitial inflammation in the kidney, and diffuse inflammatory lesions in the interstitial lung (arrow) (× 200, scale bar = 100 μm); N6 treatment group: There is a reduced density of lymphocytes in the local splenic nodules and a small infiltration of inflammatory cells in the interstitial lung (arrow) (× 200, scale bar = 100 μm); N6-COOH-miniPEG treatment group: The splenic nodules are mildly enlarged, the renal tubules are partially atrophied and a small amount of inflammatory cell infiltration is present in the interstitial lung (arrow) (× 200, scale bar = 100 μm); PMB treatment group: Reactive enlargement of splenic nodules, atrophy of the renal tubules at the site of the lesion and infiltration of inflammatory cells in the interstitial lung (arrow) (× 200, scale bar = 100 μm)