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Table 1 Genetic mutations found in K. pneumoniae isolates generated from stepwise (SW) and single high dose (HD) exposure to AgNO3

From: Mutations in SilS and CusS/OmpC represent different routes to achieve high level silver ion tolerance in Klebsiella pneumoniae

Strain

Adaptation

SilSa

CusS

OmpC

Other

NCTC 13443

SW

A13V, W353R

   

HD

L12F

  

E46V molecular chaperone

KPUK04a

SW

L322Q

   

HD

G210E

  

W57R malate dehydrogenase

KPTR8

SW

A352D

   

HD

F321C

   

18

SW

S304Y

   

HD

A352D, K255N

  

E650H TonB-dependent siderophore receptor

CFI_014_VIM-4

SW

Deletion 6 nucleotides after n1309

   

HD

S196I

  

P49T ABC transporter substrate binding protein

CFI_124_NDM-1 OXA-232

SW

 

L9Q

transposon insertion in ompC

 

HD (Died)

    

CFI_134_NDM-1

SW

 

P273L

16 kb fragment deletion including ompC

 

HD (Died)

    
  1. aWhere two mutations are shown it is because they are in different sequenced clones