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Table 4 Targets and biological functions of studied miRNAs in intestinal permeability

From: Modulation of microRNAs and claudin-7 in Caco-2 cell line treated with Blastocystis sp., subtype 3 soluble total antigen

miRNAs

Targetd factors/pathways

Biological functions

Attributed diseases

Ref

mir-16

Claludin-2

Cingulin

P38 MAP kinase

P53 phosphorylation

Barrier function dysregulation

Apoptosis

Ulcerative colitis (UC)

Crohn’s disease (CD)

IBS

Colorectal adenocarcinoma

[54,55,56,57,58,59,60]

mir-21

Rho-associated protein kinase 1(ROCK1)

PTEN/PI3K/AKT Signaling

PTEN/ PDCD4/ROCK1

Tight junctions (occludin)

ADP ribosylation factor 4 (ARF4)

Regulates tight junction proteins

Protects intestinal barrier from dysfunction

Regulates intestinal tight junction

Permeability of the intestinal barrier

Inflammation

IBD

[54, 56,57,58, 61,62,63,64]

mir-29a

Vascular endothelial growth factor A (VEGF-A)

Telomerase Reverse Transcriptase (TERT)

Integrin B1 (ITGB1)

Roundabout guidance receptor 1 (ROBO 1)

APC domain containing 2 (p42.3 or SAPCD2)

Cyclin-dependent kinase (CDK) 2, 4, and 6

Vascular endothelial growth factor (VEGF)

Tight junction proteins

Inhibiting metastasis related genes

Inhibiting cell proliferation of GC cells

Suppressed angiogenesis

Apoptosis

Intestinal barrier integrity

UC

Gastric cancer (GC)

CD

[54, 59, 65,66,67,68,69,70]

mir-223

RAS p21 GTPase-activating protein 1 (RASA1)

Claudin-8 (CLDN8)

Proliferation

Pro-inflammatory

Mediates the cross-talk between the IL23 pathway and the intestinal barrier in IBD

Non-inflamed UC

Non-inflamed CD

IBD

[57, 59, 71, 72]

mir-874

Aquaporins (AQPs)

Signal transducer and activator of transcription (STAT)3

YAP/TAZ signaling

X-linked inhibitor of apoptosis protein (XIAP)

Promotes intestinal barrier dysfunction

Anti-oncomir

Drug resistance

Intestinal ischemic injury

Esophageal squamous cell carcinoma (ESCC)

Colorectal cancer (CRC)

[73,74,75,76,77]

  1. Note: miRNA and mir microRNA, UC ulcerative colitis, CD Crohn’s disease, IBS irritable bowel syndrome, IBD inflammatory bowel diseases, GC gastric cancer