miRNAs | Targetd factors/pathways | Biological functions | Attributed diseases | Ref |
---|---|---|---|---|
mir-16 | Claludin-2 Cingulin P38 MAP kinase P53 phosphorylation | Barrier function dysregulation Apoptosis | Ulcerative colitis (UC) Crohn’s disease (CD) IBS Colorectal adenocarcinoma | |
mir-21 | Rho-associated protein kinase 1(ROCK1) PTEN/PI3K/AKT Signaling PTEN/ PDCD4/ROCK1 Tight junctions (occludin) ADP ribosylation factor 4 (ARF4) | Regulates tight junction proteins Protects intestinal barrier from dysfunction Regulates intestinal tight junction Permeability of the intestinal barrier Inflammation | IBD | |
mir-29a | Vascular endothelial growth factor A (VEGF-A) Telomerase Reverse Transcriptase (TERT) Integrin B1 (ITGB1) Roundabout guidance receptor 1 (ROBO 1) APC domain containing 2 (p42.3 or SAPCD2) Cyclin-dependent kinase (CDK) 2, 4, and 6 Vascular endothelial growth factor (VEGF) Tight junction proteins | Inhibiting metastasis related genes Inhibiting cell proliferation of GC cells Suppressed angiogenesis Apoptosis Intestinal barrier integrity | UC Gastric cancer (GC) CD | |
mir-223 | RAS p21 GTPase-activating protein 1 (RASA1) Claudin-8 (CLDN8) | Proliferation Pro-inflammatory Mediates the cross-talk between the IL23 pathway and the intestinal barrier in IBD | Non-inflamed UC Non-inflamed CD IBD | |
mir-874 | Aquaporins (AQPs) Signal transducer and activator of transcription (STAT)3 YAP/TAZ signaling X-linked inhibitor of apoptosis protein (XIAP) | Promotes intestinal barrier dysfunction Anti-oncomir Drug resistance | Intestinal ischemic injury Esophageal squamous cell carcinoma (ESCC) Colorectal cancer (CRC) |