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Table 2 MICs and FICIs of celastrol and tested antibiotics against S. aureus ATCC 6538

From: Celastrol mitigates staphyloxanthin biosynthesis and biofilm formation in Staphylococcus aureus via targeting key regulators of virulence; in vitro and in vivo approach

Agent

MIC (μg∕mL)

 

FIC

FICI

Interpretation

Alone

Combination

Celastrol

1

0.25

0.25

0.31

S

Ampicillin

8

0.5

0.06

Celastrol

1

0.25

0.25

0.31

S

Cefotaxime

4

0.25

0.06

Celastrol

1

0.06

0.06

0.12

S

Azithromycin

1

0.06

0.06

Celastrol

1

0.06

0.06

0.185

S

Ciprofloxacin

2

0.25

0.125

Celastrol

1

0.06

0.06

0.12

S

Gentamycin

2

0.12

0.06

  1. FIC Fractional inhibitory concentration, FICI Fractional inhibitory concentration index, S Synergism
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BMC Microbiology

ISSN: 1471-2180

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