Fig. 7From: Celastrol mitigates staphyloxanthin biosynthesis and biofilm formation in Staphylococcus aureus via targeting key regulators of virulence; in vitro and in vivo approachCelastrol altered the expression of S. aureus genes. RT-qPCR revealed decreased expression of STX and biofilm related genes in celastrol treated S. aureus relative to untreated bacteria. The expression levels of crtM, crtN, sigB, katA, sodM, sodA, sarA, agrA, icaA, icaR, msaB and yjbH were analyzed by qRT-PCR in both celastrol treated and untreated S. aureus. The data shown are the means ± standard errors from triplicate experiments with three technical replicates each. A P value < 0.05 was considered statistically significant using Student’s t testBack to article page