Table 2 Antimicrobial resistance genes in the genome of K. pneumoniae K85

Antibiotic efflux

arlR; baeR; kdpE; adeR; Escherichia coli CpxR; facT; emrB; cpxA; leuO; bcr-1; bcrA; emrD; floR; hmrM; hp1181; lmrB; lrfA; macA; macB; mdfA; mdtG; mdtH; mdtK; mdtL; mdtM; mdtN; mdtO; mdtP; mexJ; msbA; msrB; norB; oleC; patA; patB; rosA; rosB; salA; sav1866; taeA; tcmA; tet(A); tetA(48); tetA(60); tetB(60); tolC; vgaB; yojI; Enterobacter cloacae rob; Escherichia coli rob; marA; ramA; acrE; adeF; adeL; adeS; baeS; cmeB; crp; emrA; emrK; emrR; emrY; Escherichia coli acrA; evgA; evgS; H-NS; mdtA; mdtF; mexA; mexK; muxB; oprM; oprZ; oqxA; sdiA; smeC; tcr3

179

Antibiotic inactivation

aadA16; aph (3′)-Ia; acc (6′)-Ib-cr; bla_CTX-M-3; bla_SHV-93; bla_TEM-1; nmcR; fosA5; mphA; mrx; cmlv; arr-3; iri; rphB

19

Antibiotic inactivation, antibiotic target alteration

tet34

1

Antibiotic target alteration

vanRF; vanRE; vanRM; vanG; vanHB; gyrB; parY; EF-Tu; gyrA; UhpT; murA; kasA; katG; ndh; ileS; cls; acrS; soxR; clbB; rlmA (II); arnA; eptB; pmrE; pmrF; bacA

30

Antibiotic target alteration, antibiotic efflux

basR; basS

2

Antibiotic target protection

mfd; qnrB2; qnrS1; tetT; vanRI; vanHD; vanTC; vanTN; pmrC

12

Antibiotic target replacement

mecC; dfrA3; dfrA5; dfrE; sul1; sul3

8

Reduced permeability to antibiotic, resistance by absence

E. coli LamB

2

Reduced permeability to antibiotic

K. pneumoniae OmpK37

5