|
Species
|
N
|
beta coefficient2
|
SEM
|
P-value
|
PFDR
|
|---|
|
F.coprococcus.sp.art55.1
|
148
|
0.0100
|
0.0030
|
0.001
|
0.02
|
|
F.faecalibacterium.prausnitzii
|
901
|
0.0104
|
0.0034
|
0.002
|
0.03
|
|
B.alistipes.shahii
|
712
|
0.0052
|
0.0019
|
0.006
|
0.045
|
|
F.butyrivibrio.crossotus
|
119
|
0.0069
|
0.0025
|
0.007
|
0.045
|
|
E.methanobrevibacter.smithii
|
376
|
0.0045
|
0.0017
|
0.007
|
0.046
|
|
F.flavonifractor.plautii
|
386
|
-0.0017
|
0.0005
|
< 0.0001
|
0.02
|
|
F.lachnospiraceae.bacterium.1.4.56FAA
|
339
|
-0.0018
|
0.0006
|
0.001
|
0.02
|
|
F.clostridium.bolteae
|
453
|
-0.0046
|
0.0014
|
0.001
|
0.02
|
|
F.clostridium.symbiosum
|
317
|
-0.0017
|
0.0006
|
0.002
|
0.03
|
|
P.escherichia.coli
|
395
|
-0.0087
|
0.0028
|
0.002
|
0.03
|
|
F.blautia.hydrogenotrophica
|
260
|
-0.0015
|
0.0005
|
0.004
|
0.04
|
|
F.veillonella.parvula
|
317
|
-0.0018
|
0.0006
|
0.004
|
0.04
|
|
F.clostridium.leptum
|
682
|
-0.0043
|
0.0015
|
0.004
|
0.04
|
|
F.ruminococcus.sp.5.1.39BFAA
|
438
|
-0.0104
|
0.0036
|
0.004
|
0.04
|
|
F.clostridium.hathewayi
|
344
|
-0.0014
|
0.0005
|
0.006
|
0.045
|
|
B.bacteroides.fragilis
|
471
|
-0.0051
|
0.0018
|
0.006
|
0.045
|
|
B.alistipes.onderdonkii
|
750
|
-0.0076
|
0.0028
|
0.006
|
0.045
|
|
B.bacteroides.dorei
|
639
|
-0.0074
|
0.0027
|
0.007
|
0.045
|
- Abbreviations: A Actinobacteria, B Bacteroidetes, F Firmicutes, P Proteobacteria, E (Archaea) Euryarchaeota, N means the number of samples (out of the 911 samples) with the species detected
- 1Analyzed using MaAsLin 2 adjusted for repeated measurements (participants ID as random intercept), age (year), energy intake (kcal/day), alcohol (g/day), smoking (currently smoking cigarettes or not), physical activity (METs-h/week), using of antibiotics (yes vs. no), consumed any probiotics (yes vs. no), body mass index at age 21 (kg/m2) and fecal sample characteristics (6 category groups from hard to soft stool)
- 2beta coefficients: relative abundance of species associated with per standard deviation of enterolactone levels, where enterolactone is batch-corrected log-transformed and in unit of per standard deviation; relative abundance of species was standardized and normalized via arc-sin square root transformation
- PFDR P values after false discovery rate (FDR) correction following the Benjamini–Hochberg method
