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Table 2 Multivariable-adjusted associations1 between plasma enterolactone and relative abundances of species

From: Dietary lignans, plasma enterolactone levels, and metabolic risk in men: exploring the role of the gut microbiome

Species N beta coefficient2 SEM P-value PFDR
F.coprococcus.sp.art55.1 148 0.0100 0.0030 0.001 0.02
F.faecalibacterium.prausnitzii 901 0.0104 0.0034 0.002 0.03
B.alistipes.shahii 712 0.0052 0.0019 0.006 0.045
F.butyrivibrio.crossotus 119 0.0069 0.0025 0.007 0.045
E.methanobrevibacter.smithii 376 0.0045 0.0017 0.007 0.046
F.flavonifractor.plautii 386 -0.0017 0.0005  < 0.0001 0.02
F.lachnospiraceae.bacterium.1.4.56FAA 339 -0.0018 0.0006 0.001 0.02
F.clostridium.bolteae 453 -0.0046 0.0014 0.001 0.02
F.clostridium.symbiosum 317 -0.0017 0.0006 0.002 0.03
P.escherichia.coli 395 -0.0087 0.0028 0.002 0.03
F.blautia.hydrogenotrophica 260 -0.0015 0.0005 0.004 0.04
F.veillonella.parvula 317 -0.0018 0.0006 0.004 0.04
F.clostridium.leptum 682 -0.0043 0.0015 0.004 0.04
F.ruminococcus.sp.5.1.39BFAA 438 -0.0104 0.0036 0.004 0.04
F.clostridium.hathewayi 344 -0.0014 0.0005 0.006 0.045
B.bacteroides.fragilis 471 -0.0051 0.0018 0.006 0.045
B.alistipes.onderdonkii 750 -0.0076 0.0028 0.006 0.045
B.bacteroides.dorei 639 -0.0074 0.0027 0.007 0.045
  1. Abbreviations: A Actinobacteria, B Bacteroidetes, F Firmicutes, P Proteobacteria, E (Archaea) Euryarchaeota, N means the number of samples (out of the 911 samples) with the species detected
  2. 1Analyzed using MaAsLin 2 adjusted for repeated measurements (participants ID as random intercept), age (year), energy intake (kcal/day), alcohol (g/day), smoking (currently smoking cigarettes or not), physical activity (METs-h/week), using of antibiotics (yes vs. no), consumed any probiotics (yes vs. no), body mass index at age 21 (kg/m2) and fecal sample characteristics (6 category groups from hard to soft stool)
  3. 2beta coefficients: relative abundance of species associated with per standard deviation of enterolactone levels, where enterolactone is batch-corrected log-transformed and in unit of per standard deviation; relative abundance of species was standardized and normalized via arc-sin square root transformation
  4. PFDR P values after false discovery rate (FDR) correction following the Benjamini–Hochberg method