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Table 2 Multivariable-adjusted associations1 between plasma enterolactone and relative abundances of species

From: Dietary lignans, plasma enterolactone levels, and metabolic risk in men: exploring the role of the gut microbiome

Species

N

beta coefficient2

SEM

P-value

PFDR

F.coprococcus.sp.art55.1

148

0.0100

0.0030

0.001

0.02

F.faecalibacterium.prausnitzii

901

0.0104

0.0034

0.002

0.03

B.alistipes.shahii

712

0.0052

0.0019

0.006

0.045

F.butyrivibrio.crossotus

119

0.0069

0.0025

0.007

0.045

E.methanobrevibacter.smithii

376

0.0045

0.0017

0.007

0.046

F.flavonifractor.plautii

386

-0.0017

0.0005

 < 0.0001

0.02

F.lachnospiraceae.bacterium.1.4.56FAA

339

-0.0018

0.0006

0.001

0.02

F.clostridium.bolteae

453

-0.0046

0.0014

0.001

0.02

F.clostridium.symbiosum

317

-0.0017

0.0006

0.002

0.03

P.escherichia.coli

395

-0.0087

0.0028

0.002

0.03

F.blautia.hydrogenotrophica

260

-0.0015

0.0005

0.004

0.04

F.veillonella.parvula

317

-0.0018

0.0006

0.004

0.04

F.clostridium.leptum

682

-0.0043

0.0015

0.004

0.04

F.ruminococcus.sp.5.1.39BFAA

438

-0.0104

0.0036

0.004

0.04

F.clostridium.hathewayi

344

-0.0014

0.0005

0.006

0.045

B.bacteroides.fragilis

471

-0.0051

0.0018

0.006

0.045

B.alistipes.onderdonkii

750

-0.0076

0.0028

0.006

0.045

B.bacteroides.dorei

639

-0.0074

0.0027

0.007

0.045

  1. Abbreviations: A Actinobacteria, B Bacteroidetes, F Firmicutes, P Proteobacteria, E (Archaea) Euryarchaeota, N means the number of samples (out of the 911 samples) with the species detected
  2. 1Analyzed using MaAsLin 2 adjusted for repeated measurements (participants ID as random intercept), age (year), energy intake (kcal/day), alcohol (g/day), smoking (currently smoking cigarettes or not), physical activity (METs-h/week), using of antibiotics (yes vs. no), consumed any probiotics (yes vs. no), body mass index at age 21 (kg/m2) and fecal sample characteristics (6 category groups from hard to soft stool)
  3. 2beta coefficients: relative abundance of species associated with per standard deviation of enterolactone levels, where enterolactone is batch-corrected log-transformed and in unit of per standard deviation; relative abundance of species was standardized and normalized via arc-sin square root transformation
  4. PFDR P values after false discovery rate (FDR) correction following the Benjamini–Hochberg method