Fig. 1
Plasma enterolactone according to dietary lignans and species score. (A) Enterolactone increased with deciles of enterolactone species score (P trend < 0.0001); (B) Association between dietary lignan and enterolactone stratified by enterolactone species score (P for interaction<0.001; Among group with low species score: Beta: 4.0; SE: 1.7nM per SD lignan, P trend <0.0001; Among group with high species score: Beta: 20.7; SE: 2.3nM per SD lignan, P trend <0.0001); (C) Enterolactone according to joint classification of dietary lignan and enterolactone species score. *Generalized linear mixed-effects regressions adjusted for repeated measurements (participant ID as random intercept), age (year), energy intake (kcal/day), alcohol (g/day), smoking (currently smoking cigarettes or not), physical activity (METs-h/week), using of antibiotics (yes vs. no), consumed any probiotics (yes vs. no), body mass index at age 21 (kg/m2) and fecal sample characteristics (6 category groups from hard to soft stool)