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Fig. 5 | BMC Microbiology

Fig. 5

From: Pharmacologically induced weight loss is associated with distinct gut microbiome changes in obese rats

Fig. 5

Sibutramine treatment impacts on the microbiome. A PCA of β diversity amongst sibutramine-treated (group H, triangles) and control (group A, circles) samples at day − 3 (pre) and day 42, calculated on relative abundances by Bray-Curtis distance between each sample, using the phyloseq R/Bioconductor package [41]. B PCA of β diversity amongst taxa, calculated as in A. C Bar plot summarizing the percent composition of the top 5 phyla across control (left panel) or sibutramine (right panel) samples, at the start (pre, top) or the end (Day 42, bottom) of the treatment. D Boxplots of the comparison of Ratio of Bacteroidetes/Firmicutes between Day − 3 and Day 42 of Ctrl and sibutramine (Sib)-treated group. Statistical significance was assessed by T-test. Statistical significance levels: ns P > 0.05; * P < 0.05; ** P < 0.01; *** P < 0.00 (Control: N = 12; sibutramine: N = 10 rats per group)

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