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Fig. 1 | BMC Microbiology

Fig. 1

From: Variants associated with Bedaquiline (BDQ) resistance identified in Rv0678 and efflux pump genes in Mycobacterium tuberculosis isolates from BDQ naïve TB patients in Pakistan

Fig. 1

Single nucleotide polymorphisms (SNPs) found in efflux pump genes (n = 10) screened in Mycobacterium tuberculosis isolates having phenotypic resistance or raised minimum inhibitory concentration (MICs) to BDQ. The circles show MTB isolates (S1-S10, S20-S23) with SNPs identified in their efflux pump genes. Pink circles include BDQ resistant (MIC ≥ 0.5 µg/ml) isolates. Blue circles include susceptible isolates with raised BDQ MICs (MIC = 0.25 µg/ml). Red font depicts strains without genomic variants in rv0678 gene. SNPs in efflux pump genes M74T (Rv0194c), R426H (Rv0507c), Q243R (Rv1218c), G462K (Rv1273c), E198R (Rv1634c), P156T (Rv2688c) had a high Polyphen/SIFT score (SAR/ZH unpublished literature)

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BMC Microbiology

ISSN: 1471-2180

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