Position | Amino acid | Genotype | Resistant % (n) | Sensitive % (n) | χ2 | p value |
---|---|---|---|---|---|---|
315 | Glu | mt | 52.9 (9) | 32.8 (20) | 2.312 | 0.128 |
Lys | wt | 47.1 (8) | 67.2 (41) | |||
366 | Leu | mt | 78.9 (15) | 24.2 (16) | 19.055 | < 0.001 |
Phe | wt | 21.1 (4) | 75.8 (50) | |||
406 | Ala | mt | 5.3 (1) | 4.5 (3) | 0.017 | 1.000* |
Glu | wt | 94.7 (18) | 95.5 (63) | |||
414 | Arg | mt | 78.9 (15) | 13.6 (9) | 31.056 | < 0.001* |
Ser | wt | 21.1 (4) | 86.4 (57) | |||
417 | Thr | mt | 0.0 (0) | 1.5 (1) | 0.291 | 1.000* |
Ser | wt | 100 (19) | 98.5 (65) | |||
Ins 464–465 | Glu/Asn | mt | 57.9 (11) | 25.8 (17) | 6.898 | 0.009 |
– | wt | 42.1 (8) | 74.2 (49) | |||
469 | Met | mt | 21.1 (4) | 3.0 (2) | 7.304 | 0.021* |
Val | wt | 78.9 (15) | 97.0 (64) | |||
473 | Val | mt | 84.2 (16) | 25.8 (17) | 21.223 | < 0.001* |
Phe | wt | 15.8 (3) | 74.2 (49) | |||
474 | Val | mt | 0.0 (0) | 7.6 (5) | 1.529 | 0.583* |
Ala | wt | 100 (19) | 92.4 (61) | |||
479 | Glu | mt | 68.4 (13) | 87.9 (58) | 4.060 | 0.044 |
Asp | wt | 31.6 (6) | 12.1 (8) | |||
504 | Asn | mt | 73.7 (14) | 80.3 (53) | 0.387 | 0.534 |
Asp | wt | 26.3 (5) | 19.7 (13) | |||
508 | Asn | mt | 31.6 (6) | 24.2 (16) | 0.414 | 0.520 |
Asp | wt | 68.4 (13) | 75.8 (50) | |||
509 | Ile | mt | 31.6 (6) | 18.2 (12) | 1.586 | 0.208 |
Val | wt | 68.4 (13) | 81.8 (54) | |||
515 | Ile | mt | 52.6 (10) | 62.1 (41) | 0.554 | 0.457 |
Met | wt | 47.4 (9) | 37.9 (25) | |||
543 | Arg | mt | 26.3 (5) | 25.8 (17) | 0.002 | 0.961 |
Ser | wt | 73.7 (14) | 74.2 (49) | |||
556 | Ser | mt | 0.0 (0) | 4.5 (3) | 0.895 | 1.000* |
Thr | wt | 100 (19) | 95.5 (63) | |||
562 | Tyr | mt | 15.8 (3) | 3.0 (2) | 4.338 | 0.072* |
Asn | wt | 84.2 (16) | 97.0 (64) | |||
589 | Gly | mt | 100 (19) | 93.9 (62) | 1.208 | 0.571* |
Ser | wt | 0.0 (0) | 6.1 (4) | |||
593 | Ala | mt | 21.1 (4) | 18.2 (12) | 0.080 | 0.784* |
Thr | wt | 78.9 (15) | 81.8 (54) | |||
595 | Ser | mt | 15.8 (3) | 18.2 (12) | 0.058 | 1.000* |
Gly | wt | 84.2 (16) | 81.8 (54) | |||
Ins 595–596 | Gly/Ser/Ala | mt | 73.7 (14) | 32.3 (21) | 10.356 | 0.001 |
– | wt | 26.3 (5) | 67.7 (44) | |||
596 | Ile/Ala | mt | 5.3 (1) | 1.5 (1) | 0.878 | 0.403* |
Val | wt | 94.7 (18) | 98.5 (64) |