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Table 3 Relationships between amino acid substitution and amoxicillin susceptibility

From: Emergence of amoxicillin resistance and identification of novel mutations of the pbp1A gene in Helicobacter pylori in Vietnam

Position

Amino acid

Genotype

Resistant

% (n)

Sensitive

% (n)

χ2

p value

315

Glu

mt

52.9 (9)

32.8 (20)

2.312

0.128

Lys

wt

47.1 (8)

67.2 (41)

366

Leu

mt

78.9 (15)

24.2 (16)

19.055

< 0.001

Phe

wt

21.1 (4)

75.8 (50)

406

Ala

mt

5.3 (1)

4.5 (3)

0.017

1.000*

Glu

wt

94.7 (18)

95.5 (63)

414

Arg

mt

78.9 (15)

13.6 (9)

31.056

< 0.001*

Ser

wt

21.1 (4)

86.4 (57)

417

Thr

mt

0.0 (0)

1.5 (1)

0.291

1.000*

Ser

wt

100 (19)

98.5 (65)

Ins 464–465

Glu/Asn

mt

57.9 (11)

25.8 (17)

6.898

0.009

–

wt

42.1 (8)

74.2 (49)

469

Met

mt

21.1 (4)

3.0 (2)

7.304

0.021*

Val

wt

78.9 (15)

97.0 (64)

473

Val

mt

84.2 (16)

25.8 (17)

21.223

< 0.001*

Phe

wt

15.8 (3)

74.2 (49)

474

Val

mt

0.0 (0)

7.6 (5)

1.529

0.583*

Ala

wt

100 (19)

92.4 (61)

479

Glu

mt

68.4 (13)

87.9 (58)

4.060

0.044

Asp

wt

31.6 (6)

12.1 (8)

504

Asn

mt

73.7 (14)

80.3 (53)

0.387

0.534

Asp

wt

26.3 (5)

19.7 (13)

508

Asn

mt

31.6 (6)

24.2 (16)

0.414

0.520

Asp

wt

68.4 (13)

75.8 (50)

509

Ile

mt

31.6 (6)

18.2 (12)

1.586

0.208

Val

wt

68.4 (13)

81.8 (54)

515

Ile

mt

52.6 (10)

62.1 (41)

0.554

0.457

Met

wt

47.4 (9)

37.9 (25)

543

Arg

mt

26.3 (5)

25.8 (17)

0.002

0.961

Ser

wt

73.7 (14)

74.2 (49)

556

Ser

mt

0.0 (0)

4.5 (3)

0.895

1.000*

Thr

wt

100 (19)

95.5 (63)

562

Tyr

mt

15.8 (3)

3.0 (2)

4.338

0.072*

Asn

wt

84.2 (16)

97.0 (64)

589

Gly

mt

100 (19)

93.9 (62)

1.208

0.571*

Ser

wt

0.0 (0)

6.1 (4)

593

Ala

mt

21.1 (4)

18.2 (12)

0.080

0.784*

Thr

wt

78.9 (15)

81.8 (54)

595

Ser

mt

15.8 (3)

18.2 (12)

0.058

1.000*

Gly

wt

84.2 (16)

81.8 (54)

Ins 595–596

Gly/Ser/Ala

mt

73.7 (14)

32.3 (21)

10.356

0.001

–

wt

26.3 (5)

67.7 (44)

596

Ile/Ala

mt

5.3 (1)

1.5 (1)

0.878

0.403*

Val

wt

94.7 (18)

98.5 (64)

  1. Coinfection samples were excluded from the analysis; (*) Fisher’s exact test was applied; (wt) wild-type; (mt) mutant (amino acid is different from strain 26,695)