In vitro activities of thiazolidione derivatives combined with daptomycin against clinical Enterococcus faecium strains

Table 1 Biological activities of the two thiazolidione derivatives

Compounds	Molecular formula	MW	MIC^a (μM)	MBC^a (μM)	IC₅₀^b (μM)
H2-60	C₂₇H₁₆F₂N₂O₃S₂	518	3.13	12.5	25.4
H2-81	C₂₇H₁₇FN₂O₃S₂	500	3.13	12.5	26.2
Ampicillin	C₁₆H₁₈N₃NaO₄S	371	2.70	10.8	ND
Vancomycin	C₆₆H₇₅Cl₂N₉O₂₄·HCl	1486	0.67	2.7	ND
Linezolid	C₁₆H₂₀FN₃O₄	337	5.93	23.7	ND
Daptomycin	C₇₂H₁₀₁N₁₇O₂₆	1621	0.62	2.48	ND

MW molecular weight, ND not detect
^a MIC (minimal inhibitory concentration) and MBC (minimal bactericidal concentration) against E. faecium EF16M64
^bIC₅₀ represents the concentration of the YycG in inhibitors that inhibited 50% of the autophosphorylation of YycG′ detected by Kinase-Glo Luminescent kit

ISSN: 1471-2180