Proteome and secretome profiling of zinc availability in Cryptococcus neoformans identifies Wos2 as a subtle influencer of fungal virulence determinants

Table 1 Proteins with significant changes in abundance from cell pellet (cellular proteome) and supernatant (secretome) profiling of C. neoformans H99 under zinc-limited and -replete conditions

				Difference (log₂)^b
	Gene name^a	Protein name	Function	Limited	Replete
Cellular proteome
	CNAG_00895	Solute carrier family 39	Transport	5.84
	CNAG_01290	Uncharacterized protein	Uncharacterized		6.00
	CNAG_02548	Cobalamin synthesis protein	Biosynthesis	7.69
	CNAG_03127	Small subunit ribosomal protein S23	Translation		5.63
Secretome
	CNAG_00483	Actin	Structure	4.26
	CNAG_03891	Hsp60-like protein	Protein refolding		2.12
	CNAG_04448	Ribosomal protein L19	Translation		1.12
	CNAG_04640	ATP-citrate synthase	Biosynthesis	1.17
	CNAG_07558	CS domain-containing protein (Wos2)	Uncharacterized		1.21

^aProteins presented according to numerical order of gene identifiers (i.e., CNAG number)
^bValues presented as positive relative to each comparison

ISSN: 1471-2180