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Fig. 4 | BMC Microbiology

Fig. 4

From: Proteome and secretome profiling of zinc availability in Cryptococcus neoformans identifies Wos2 as a subtle influencer of fungal virulence determinants

Fig. 4

Secretome profiling of zinc limitation in C. neoformans. A Venn diagram for number of unique proteins identified in the secretome under zinc-limited (3; grey) and zinc-replete (5; purple) conditions with 14 proteins commonly identified. B PCA plot of C. neoformans biological replicates under limited (grey) and replete (purple) conditions; clustering based on growth conditions (component 1) and biological variability (component 2). C Volcano plot depicting all proteins identified under zinc-limited and -replete (10 μM) conditions, highlighting proteins with significant increases or decreases in abundance during limited (grey) and replete (purple) conditions. Student’s t-test, p-value ≤ 0.05; FDR = 0.05; S0 = 1. D STRING network analysis of predicted and known interacting partners of significantly increased Wos2 (CNK01080; highlighted in red) under replete conditions. E STRING interacting partners of Wos2, including protein name and function. Experiment performed in biological quadruplicate

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BMC Microbiology

ISSN: 1471-2180

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