Intra-wound vancomycin powder for the eradication of periprosthetic joint infection after debridement and implant exchange: experimental study in a rat model

Table 1 Mean colony-forming units (CFUs) data from Fig. 4C–F

Group	Bone	Prosthesis	Soft tissue	Total
Control	1.19 × 10⁴ ± 6.76 × 10³	1.03 × 10⁴ ± 5.93 × 10³	1.02 × 10⁴ ± 6.51 × 10³	3.26 × 10⁴ ± 1.32 × 10⁴
SV	269 ± 237	313 ± 234	307 ± 219	889 ± 549
VP	660 ± 469	414 ± 292	427 ± 313	1501 ± 658
SV&VP	0	0	0	0

Control (no antibiotics); SV Systemic vancomycin (intraperitoneal injection, 88 mg/kg, every 12 h), VP Intra-wound vancomycin powder (before closure of the capsule, 88 mg/kg, single dosage), SV&VP Systemic vancomycin & intra-wound VP (intraperitoneal injection, 88 mg/kg, every 12 h; combined with intra-wound VP before closure of the capsule, 88 mg/kg, single dosage). n = 10

ISSN: 1471-2180