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Table 1 Annotations and predicted functions of genes in the IslAB gene cluster. All initial annotations were taken from the original IMG annotation for Bilophila wadsworthia 3.1.6. The prefix to yield a complete IMG locus tag is HMPREF0179_

From: Bacterial microcompartments for isethionate desulfonationĀ in the taurine-degrading human-gut bacterium Bilophila wadsworthia

Locus tag

Annotation

Predicted gene product function

00636

TIGR04076 family protein

potentially involved in redox reactions or iron cluster metabolism

00637

PAS domain S-box-containing protein

transcriptional regulator

00638

pyruvate formate lyase activating enzyme

IslA-activating enzyme, IslB (confirmed, see [1])

00639

formate C-acetyltransferase

isethionate sulfite-lyase, IslA (confirmed, see [1])

00640

aldehyde dehydrogenase

acetylating acetaldehyde dehydrogenase (confirmed, see [1])

00641

ethanolamine utilization protein EutN

BMC shell protein [28, 29]

00642

ethanolamine utilization protein EutN

BMC shell protein [28, 29]

00643

phosphotransacetylase

phosphotransacetylase

00644

ethanolamine utilization cobalamin adenosyltransferase

unclear (see Discussion)

00645

ethanolamine utilization protein EutQ

putative acetate kinase [30]

00646

BMC domain-containing shell protein

Ā 

00647

Carboxysome shell and ethanolamine utilization microcompartment protein CcmL/EutN

protein alignment (BLAST) revealed it to be also similar to PduT, a shell protein from propanediol utilization microcompartments that contain 4Fe-4Ā S cluster [31,32,33] (see also Discussion)

00648

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF (RnfC subunit)

based on its four protein family (pfam) domains, we conclude it to be a PduS homolog (see Discussion)

00649

hypothetical protein

predicted amidohydrolase function (IMG)