Fig. 1

Differential abundances of modules and pathways between healthy infants and infants with CF during the first year of life. Each cell in the heatmap represents the log₁₀ ratio of the median abundances of controls to CF. Modules/pathways are grouped vertically by temporal pattern of significant differential abundance (q < 0.01, Wilcoxon rank-sum test). Significance labels indicate at which time points and in which cohort the function was significantly increased in one cohort relative to the other (CF for significantly increased in infants with CF, Control for significantly increased in healthy controls, and ns for not significant). Sample sizes at each time point are indicated in the x-axis label