Table 2 Low abundant species and their presence in control and AD patients at different skin sites
| Â | Pos. individuals | Â | Mean relative abundance (%) | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(>  0% at one site)/total | Nasal | Periorbital | Perioral | Neck | Upper inner arms | Antecubital flexures | Volar forearms | Dorsum of hands | Palmar hands | Between fingers | Popliteal flexures | Dorsum of feet | Arches of feet | Between toes | |||||||||||||||||
Species | C | AD | Subjects with site(s) ≥ 1% | C | AD | C | AD | C | AD | C | AD | C | AD | C | AD | C | AD | C | AD | C | AD | C | AD | C | AD | C | AD | C | AD | C | AD |
M. osloensis | 5/5 | 9/9 | AD2, AD3, AD4, AD8, AD9 | 0.0 | 0.1 | 0.0 | 0.2 | 0.0 | 0.1 | 0.0 | 0.5 | 0.2 | 1.6 | 0.1 | 0.4 | 0.1 | 1.5 | 0.1 | 1.2 | 0.1 | 0.8 | 0.1 | 2.7 | 0.2 | 0.6 | 0.2 | 0.4 | 0.2 | 0.1 | 0.0 | 2.4 |
P. yeei | 5/5 | 7/9 | AD3 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.2 | 0.1 | 0.2 | 1.5 | 0.0 | 0.3 | 0.3 | 0.1 | 0.0 | 0.0 | 0.0 | 2.4 | 0.2 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 0.6 |
Rothia sp. ND6WE1A | 0/5 | 3/9 | AD9 | 0.0 | 0.2 | 0.0 | 0.0 | 0.0 | 0.8 | 0.0 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.5 | 0.0 | 0.5 | 0.0 | 1.1 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.0 |
Malassezia globosa | 5/5 | 8/9 | C5, C6, C8, C9, C10, AD2, AD6 | 0.0 | 0.4 | 0.1 | 0.2 | 0.5 | 0.3 | 2.0 | 0.2 | 0.4 | 0.1 | 1.3 | 0.1 | 1.6 | 0.2 | 0.3 | 0.0 | 0.3 | 0.2 | 0.2 | 0.1 | 0.1 | 0.0 | 0.1 | 0.2 | 0.1 | 0.0 | 0.0 | 0.0 |
Malasseziales sp. | 5/5 | 9/9 | C5, C6, C8, C9, C10, AD6, AD8 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 1.1 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.2 | 0.1 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Staphylococcus saccharolyticus | 1/5 | 4/9 | AD2, AD3 | 0.0 | 0.0 | 0.0 | 3.9 | 0.0 | 0.2 | 0.0 | 3.4 | 0.1 | 0.0 | 0.0 | 1.1 | 0.0 | 0.7 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Staphylococcus lugdunensis | 2/5 | 7/9 | AD9 | 0.0 | 2.6 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.8 | 0.0 | 0.2 | 0.0 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.3 | 0.0 | 0.1 | 0.0 | 0.0 |
Staphylococcus cohnii | 4/5 | 4/9 | C9, C10 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.6 | 0.1 | 2.5 | 0.0 | 0.0 | 0.0 |
Staphylococcus pasteuri | 5/5 | 8/9 | C5, C6, AD1, AD2, AD3, AD9 | 0.0 | 0.1 | 0.1 | 0.3 | 0.0 | 0.3 | 0.1 | 0.7 | 0.2 | 0.0 | 0.2 | 0.5 | 0.1 | 0.4 | 0.5 | 0.1 | 0.8 | 1.0 | 2.6 | 2.8 | 0.2 | 0.0 | 0.3 | 0.5 | 0.1 | 0.1 | 0.0 | 0.1 |
Staphylococcus haemolyticus | 5/5 | 7/9 | C5, C9, C10, AD1, AD9, AD10 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.2 | 0.0 | 0.3 | 0.1 | 0.5 | 0.1 | 1.1 | 0.0 | 0.2 | 0.5 | 0.3 | 0.4 | 0.6 | 0.3 | 0.2 | 0.8 | 0.2 | 1.7 | 2.6 | 0.6 | 1.0 | 0.1 | 8.1 |
C. singulare | 4/5 | 4/9 | C6 | 0.1 | 0.0 | 0.2 | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.3 | 0.1 | 0.4 | 0.0 | 0.0 | 0.0 | 0.6 | 0.0 | 1.7 | 0.0 | 1.2 | 0.0 | 1.3 | 0.0 | 0.4 | 0.1 | 0.4 | 0.0 | 0.0 | 0.0 |
C. appendicis | 2/5 | 1/9 | C8 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | 0.0 | 0.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.3 | 0.0 | 1.9 | 0.0 | 0.0 | 0.0 |
C. jeikeium | 5/5 | 3/9 | C9, AD8 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.1 | 0.0 | 0.1 | 0.2 | 0.1 | 0.3 | 0.0 | 0.1 | 0.3 | 0.1 | 0.4 | 0.6 | 0.3 | 0.4 | 0.1 | 1.6 | 0.0 | 0.4 | 0.5 | 0.2 | 0.0 | 0.1 | 1.7 |
C. simulans | 4/5 | 6/9 | C5, C6, AD8 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | 0.4 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 0.5 | 0.2 |
Streptococcus thermophilus | 5/5 | 8/9 | C6, C9, AD4 | 0.1 | 0.0 | 1.9 | 0.1 | 1.1 | 0.3 | 0.1 | 0.1 | 1.0 | 0.2 | 1.9 | 0.0 | 0.3 | 0.2 | 0.8 | 0.1 | 1.5 | 0.2 | 0.5 | 0.1 | 0.4 | 0.0 | 0.4 | 0.0 | 0.2 | 0.0 | 0.0 | 0.0 |
Streptococcus gordonii | 5/5 | 8/9 | C6, C8, AD1, AD10 | 0.0 | 0.0 | 0.0 | 0.3 | 1.0 | 0.8 | 0.2 | 0.1 | 0.2 | 0.0 | 0.1 | 0.1 | 0.4 | 0.2 | 0.1 | 0.1 | 0.2 | 0.6 | 0.1 | 0.7 | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 |
Streptococcus oralis | 4/5 | 8/9 | C6, C10, AD4, AD9, AD10 | 0.0 | 0.0 | 0.0 | 0.2 | 0.3 | 1.0 | 0.0 | 0.1 | 0.5 | 0.1 | 0.0 | 0.1 | 0.1 | 0.2 | 0.0 | 0.1 | 0.0 | 0.5 | 0.0 | 0.9 | 0.0 | 0.0 | 0.3 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 |
K. marina | 5/5 | 8/9 | C5, C6, AD9 | 0.3 | 0.0 | 0.8 | 0.2 | 0.7 | 0.1 | 1.9 | 0.1 | 3.2 | 0.0 | 2.5 | 0.2 | 0.4 | 0.3 | 2.5 | 0.0 | 2.0 | 0.3 | 0.7 | 0.3 | 3.1 | 0.0 | 1.5 | 0.1 | 2.1 | 0.0 | 0.0 | 0.3 |
K. palustris | 5/5 | 9/9 | AD1, AD4, AD9, AD10, C5, C6, C8, C9 | 0.1 | 0.1 | 0.4 | 0.3 | 0.2 | 0.4 | 2.0 | 0.2 | 9.5 | 0.1 | 4.5 | 0.1 | 0.6 | 0.4 | 5.0 | 0.3 | 4.2 | 3.2 | 2.0 | 2.3 | 7.5 | 0.0 | 3.2 | 2.5 | 9.0 | 0.0 | 0.1 | 0.5 |
Kocuria sp. WRN011 | 5/5 | 5/9 | C5, C6, AD1, AD9, AD10 | 0.2 | 0.0 | 0.1 | 0.3 | 0.1 | 1.1 | 0.0 | 0.1 | 0.6 | 0.0 | 0.5 | 0.1 | 0.3 | 0.1 | 0.9 | 0.0 | 0.8 | 1.0 | 0.7 | 0.3 | 0.7 | 0.0 | 0.5 | 0.3 | 0.5 | 0.0 | 0.1 | 0.2 |
Cutibacterium avidum | 5/5 | 7/9 | C8, AD1, AD8 | 1.0 | 0.6 | 0.1 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
[Propionibacterium] namnetense | 5/5 | 8/9 | C5, C10, AD4, AD6, AD10 | 0.1 | 0.0 | 0.3 | 0.6 | 0.2 | 0.6 | 0.5 | 0.3 | 0.4 | 0.0 | 1.0 | 0.0 | 0.3 | 0.2 | 0.6 | 0.1 | 0.8 | 0.4 | 1.0 | 0.1 | 0.4 | 0.0 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 |
Veillonella parvula | 4/5 | 8/9 | C6, C8, AD1, AD3, AD6, AD10 | 0.0 | 0.0 | 0.0 | 0.3 | 0.5 | 0.9 | 0.0 | 0.1 | 0.1 | 0.1 | 0.0 | 0.1 | 0.6 | 0.2 | 0.2 | 0.0 | 0.1 | 0.7 | 0.1 | 1.8 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
G. vaginalis | 3/5 | 3/9 | C8, AD2 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.0 | 0.0 | 0.0 | 0.4 | 0.1 | 0.0 | 0.1 | 0.1 | 0.0 | 3.1 | 0.0 | 0.6 | 0.2 | 2.6 | 0.0 | 0.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |