Table 1 Predicted stability changes upon mutation H364R using DUET prediction web server. The negative ΔΔGs (kcal/mol) indicate the destabilizing effect of mutation H364R
|
Method Wild-type | mCSM Predicted Stability Change (ΔΔG: kcal mol) | SDM Predicted Stability Change (ΔΔG: kcal/mol) |
DUET Predicted Stability Change (ΔΔG: kcal/mol) |
|---|---|---|---|
| 4mn5-chain A | −1.4 | −1.0 | −1.371 |
| 4mn5-chain B | −1.478 | −1.19 | −1.484 |
| 4mn6-chain A | −1.364 | −1.58 | −1.423 |
| 4mn6-chain B | −1.478 | −1.19 | −1.484 |