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Table 2 Effects of restoration of wild type Ompk35 and Ompk36 into clinical KPC-KP isolates

From: Increased gene expression and copy number of mutated blaKPC lead to high-level ceftazidime/avibactam resistance in Klebsiella pneumoniae

Strain Description MIC (mg/L)
CZA CAZ IMP MEM ATM FEP
8A clinical isolate 8A 8 ≥64 ≥16 ≥16 ≥64 ≥32
KPM30 8A + Blunt vector 4 ≥64 ≥16 ≥16 ≥64 ≥32
KPM02 8A + Blunt::ompk35_wt 4 ≥64 ≥16 ≥16 16 ≥32
KPM06 8A + Blunt::ompk36_wt 8 ≥64 ≥16 ≥16 ≥64 ≥32
1B clinical isolate 1B 2048 ≥64 1 4 ≥64 ≥32
KPM21 1B + Blunt vector 2048 ≥64 0.5 4 ≥64 ≥32
KPM10 1B + Blunt::ompk35_wt 2048 ≥64 1 ≤0.25 ≥64 ≥32
KPM11 1B + Blunt::ompk36_wt 2048 ≥64 0.5 0.5 ≥64 ≥32
3B clinical isolate 3B 512 ≥64 ≥16 ≥16 ≥64 ≥32
KPM23 3B + Blunt vector 512 ≥64 ≥16 ≥16 ≥64 ≥32
KPM01 3B + Blunt::ompk35_wt 512 ≥64 ≥16 ≥16 ≥64 ≥32
KPM05 3B + Blunt::ompk36_wt 512 ≥64 ≥16 ≥16 ≥64 ≥32
7B clinical isolate 7B 512 ≥64 2 2 ≥64 ≥32
KPM27 7B + Blunt vector 512 ≥64 2 2 ≥64 ≥32
KPM04 7B + Blunt::ompk35_wt 512 ≥64 1 2 ≥64 ≥32
KPM08 7B + Blunt::ompk36_wt 512 ≥64 1 2 ≥64 ≥32
8B clinical isolate 8B 256 ≥64 2 4 ≥64 ≥32
KPM28 8B + Blunt vector 256 ≥64 1 4 ≥64 ≥32
KPM03 8B + Blunt::ompk35_wt 256 ≥64 2 0.5 16 2
KPM07 8B + Blunt::ompk36_wt 256 ≥64 1 4 ≥64 ≥32
  1. Abbreviations: CZA ceftazidime/avibactam; CAZ ceftazidime; IMP imipenem; MEM meropenem; ATM aztreonam; FEP cefepime