Table 2 Effects of restoration of wild type Ompk35 and Ompk36 into clinical KPC-KP isolates

8A

clinical isolate 8A

8

≥64

≥16

≥16

≥64

≥32

KPM30

8A + Blunt vector

4

≥64

≥16

≥16

≥64

≥32

KPM02

8A + Blunt::ompk35_wt

4

≥64

≥16

≥16

16

≥32

KPM06

8A + Blunt::ompk36_wt

8

≥64

≥16

≥16

≥64

≥32

1B

clinical isolate 1B

2048

≥64

1

4

≥64

≥32

KPM21

1B + Blunt vector

2048

≥64

0.5

4

≥64

≥32

KPM10

1B + Blunt::ompk35_wt

2048

≥64

1

≤0.25

≥64

≥32

KPM11

1B + Blunt::ompk36_wt

2048

≥64

0.5

0.5

≥64

≥32

3B

clinical isolate 3B

512

≥64

≥16

≥16

≥64

≥32

KPM23

3B + Blunt vector

512

≥64

≥16

≥16

≥64

≥32

KPM01

3B + Blunt::ompk35_wt

512

≥64

≥16

≥16

≥64

≥32

KPM05

3B + Blunt::ompk36_wt

512

≥64

≥16

≥16

≥64

≥32

7B

clinical isolate 7B

512

≥64

2

2

≥64

≥32

KPM27

7B + Blunt vector

512

≥64

2

2

≥64

≥32

KPM04

7B + Blunt::ompk35_wt

512

≥64

1

2

≥64

≥32

KPM08

7B + Blunt::ompk36_wt

512

≥64

1

2

≥64

≥32

8B

clinical isolate 8B

256

≥64

2

4

≥64

≥32

KPM28

8B + Blunt vector

256

≥64

1

4

≥64

≥32

KPM03

8B + Blunt::ompk35_wt

256

≥64

2

0.5

16

2

KPM07

8B + Blunt::ompk36_wt

256

≥64

1

4

≥64

≥32