Fig. 2

Inter-omics Procrustes biplots comparing PCoA ordinations of targeted metabolite profiles and taxonomic relative abundances for 6 weeks (left panels) (n = 158) and 12 months (right panels) (n = 262). Top panels present analyses based on ordinations from Euclidean distances of genus level abundances after centered log ratio transformation and Euclidean distances of log-transformed metabolite profiles. Bottom panel presents analyses based on gUniFrac distance of amplicon sequence variant (ASV) relative abundances and Euclidean distances of log-transformed metabolite profiles. There were significant associations between the microbiome and the metabolome (both targeted and untargeted) when utilizing Euclidean distances, however this association goes away when the gUniFrac distance was employed for the targeted metabolites only