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Table 2 Performance of routine culture and pre-processing using tissue homogenizer using clinical infection as reference standard

From: Pre-processing tissue specimens with a tissue homogenizer: clinical and microbiological evaluation

  Sensitivity (95 %CI) Specificity (95 %CI)
All tissues (n = 104)   
 Routine procedure 89.1 (80.9 to 97.3) 61.2 (48.3 to 74.1)
 With pre- processing 83.6 (73.8 to 93.3) 63.3 (50.1 to 76.0)
Periprosthetic tissues only (n = 42)   
 Routine procedure 96.3 (91.3 to 100.0) 93.3 (86.7 to 99.9)
 With pre- processing 77.8 (66.8 to 88.8) 93.3 (86.7 to 99.9)
Bone tissues only (n = 41)   
 Routine procedure 90 (82.1 to 97.9) 71.4 (59.5 to 83.3)
 With pre- processing 95 (89.2 to 100.0) 76.2 (64.9 to 87.4)
Soft tissues only (n = 63)   
 Routine procedure 88.6 (80.2 to 97.0) 53.6 (40.4 to 66.8)
 With pre- processing 77.1 (66.0 to 88.2) 53.6 (40.4 to 66.8)
Only tissues without possible commensals (ENT and GI-tract) (n = 88)   
 Routine procedure 87.8 (79.2 to 96.4) 76.9 (65.8 to 88.0)
 With pre- processing 81.6 (71.4 to 100.0) 79.5 (68.8 to 90.2)
  1. Abbreviations: ENT: ear, nose and throat, GI: gastrointestinal