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Table 2 List of acquired non-β-lactamases resistance genes identified in A. baumannii isolates from humans (n = 14/85) based on WGS data using ResFinder databases

From: WGS based analysis of acquired antimicrobial resistance in human and non-human Acinetobacter baumannii isolates from a German perspective

Antibiotic class AMR resistant genes Mechanism Resistance pattern
Gene family Number (%)
Aminoglycosides
Antibiotic inactivation
aac.3...Ia_1 3 (21.5%) ACT: Acetyltransferase 2/3 AMK
aac.6...Iaf_1 1 (7%) ACT: Acetyltransferase AMK
aac.6...Ian_1 1 (7%) ACT: Acetyltransferase AMK
ant.2 … Ia_1 1 (7%) NUT: Nucleotidyltransferase AMK
aph.3...Ia_7 6 (43%) PHT: Phosphotransferase AMK
aph.6...Id_1 9 (64%) PHT: Phosphotransferase 7/9 AMK
armA_1 7 (50%) MET: Methyltransferase AMK
strA_1 9 (64%) NUT: Nucleotidyltransferase 7/9 AMK
Phenicoles catA1_1 1 (7%) Enzymes Inactivation CMP
catB8_1 2 (14%) Enzymes Inactivation CMP
floR_2 1 (7%) Antibiotic Efflux CMP
Macrolide-lincosamide-streptogramin B (MLS) mph. E_1 2 (14%) Enzymes Inactivation
msr. E_4 3 (21.4%) Antibiotic Efflux
Sulfonamides sul1_5 3 (21.4%) Antibiotic Target Replacement T/S
sul2_2 1 (7%) Antibiotic Target Replacement T/S
Tetracyclines tet.39._1 2 (14%) Antibiotic Efflux
tet. A_6 1 (7%) Antibiotic Efflux TGC
tet. B_1 9 (64%) Antibiotic Efflux 8/9 TGC
  1. AMK amikacin, CMP chloramphenicol, T/S trimethoprim/sulfamethoxazole, TGC tigecycline