Table 2 List of acquired non-β-lactamases resistance genes identified in A. baumannii isolates from humans (n = 14/85) based on WGS data using ResFinder databases
Antibiotic class | AMR resistant genes | Mechanism | Resistance pattern | |
|---|---|---|---|---|
Gene family | Number (%) | |||
Aminoglycosides Antibiotic inactivation | aac.3...Ia_1 | 3 (21.5%) | ACT: Acetyltransferase | 2/3 AMK |
aac.6...Iaf_1 | 1 (7%) | ACT: Acetyltransferase | AMK | |
aac.6...Ian_1 | 1 (7%) | ACT: Acetyltransferase | AMK | |
ant.2 … Ia_1 | 1 (7%) | NUT: Nucleotidyltransferase | AMK | |
aph.3...Ia_7 | 6 (43%) | PHT: Phosphotransferase | AMK | |
aph.6...Id_1 | 9 (64%) | PHT: Phosphotransferase | 7/9 AMK | |
armA_1 | 7 (50%) | MET: Methyltransferase | AMK | |
strA_1 | 9 (64%) | NUT: Nucleotidyltransferase | 7/9 AMK | |
Phenicoles | catA1_1 | 1 (7%) | Enzymes Inactivation | CMP |
catB8_1 | 2 (14%) | Enzymes Inactivation | CMP | |
floR_2 | 1 (7%) | Antibiotic Efflux | CMP | |
Macrolide-lincosamide-streptogramin B (MLS) | mph. E_1 | 2 (14%) | Enzymes Inactivation | – |
msr. E_4 | 3 (21.4%) | Antibiotic Efflux | – | |
Sulfonamides | sul1_5 | 3 (21.4%) | Antibiotic Target Replacement | T/S |
sul2_2 | 1 (7%) | Antibiotic Target Replacement | T/S | |
Tetracyclines | tet.39._1 | 2 (14%) | Antibiotic Efflux | – |
tet. A_6 | 1 (7%) | Antibiotic Efflux | TGC | |
tet. B_1 | 9 (64%) | Antibiotic Efflux | 8/9 TGC | |