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Table 2 Relationship virulence factors, antibiotic resistance and virulence, and β-lactamase regulatory genes in BSI collection of S. aureus

From: Regulation of virulence and β-lactamase gene expression in Staphylococcus aureus isolates: cooperation of two-component systems in bloodstream superbugs

Virulence factor genes Fold change of virulence and β-lactamase regulatory genes Antibiotic resistance profiles
mecRI mecI mecA blaZI RNAIII sarA RNAII
tst *** < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.034
etA < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.695
etB < 0.001 < 0.001 > 0.001 < 0.001 < 0.001 > 0.001 < 0.001 0.074
lukS-PVL < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.007
lukF-PV < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.049
lukE-lukD > 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.014
edinA > 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.019
Hla < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.082
Hlb < 0.001 < 0.001 > 0.001 < 0.001 < 0.001 > 0.001 < 0.001 0.060
Hld < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.002
Hlg < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.003
SCCmec types
SCCmecI** < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 0.004
SCCmecII < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 0.049
SCCmecIII < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 0.052
SCCmecIV < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 0.040
SCCmecV < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 0.012
  < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 0.053
Antibiotic resistant strains
 MDR* < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 0.009
 XDR < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 0.051
 PDR < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 0.069
  1. Asterisks indicate significant differences in gene expression levels between (*, P < 0.05; **, P < 0.01; ***, P < 0.001)