Drug | Locus | Nucleic acid change | Codon mutation | 2014 n (%) | 2015 n (%) | 2016 n (%) | 2017 n (%) | 2018 n (%) | 2019 n (%) | Total |
---|---|---|---|---|---|---|---|---|---|---|
INH | KatG | AGC → AAC | Ser315Asn | 4 (10.0) | 0 (0.0) * | 0 (0.0) * | 1 (2.7) | 3 (6.3) | 5 (5.2) | 13 (4.5) |
 |  | AGC → ACC | Ser315Thr | 30 (75.0) | 5 (11.1) | 10 (47.6) | 34 (91.9) | 40 (83.3) | 72 (74.2) | 191 (66.3) |
 | inhA | C → T | C(−15) → T | 0 (0.0) | 0 (0.0) | 1 (4.8) | 2 (5.4) | 5 (10.4) | 15 (15.5) * | 23 (8.0) |
 | KatG + inhA | AGC → ACC + C → T | Ser315Thr + C(−15) → T | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (3.1) | 3 (1.0) |
 | Other locus | Other mutations | Other substitutions | 6 (15.0) | 40 (88.9) * | 10 (47.6) * | 0 (0.0) * | 0 (0.0) * | 2 (2.1) * | 58 (20.1) |
Total | Â | Â | Â | 40 (100.0) | 45 (100.0) | 21 (100.0) | 37 (100.0) | 48 (100.0) | 97 (100.0) | 288 (100.0) |
RIF | ||||||||||
 | rpoB | CTG → CCG | Leu511Pro | 8 (17.0) | 1 (1.8) * | 1 (2.6) * | 3 (6.4) | 4 (5.8) | 10 (8.1) | 27 (7.1) |
 |  | CAA → CCA | Gln513Pro | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.8) | 1 (0.3) |
 |  | CAA → AAA | Gln513Lys | 2 (4.3) | 0 (0.0) | 1 (2.6) | 1 (2.1) | 1 (1.5) | 0 (0.0) | 5 (1.3) |
 |  | GAC → GGC | Asp516Gly | 0 (0.0) | 1 (1.8) | 0 (0.0) | 0 (0.0) | 1 (1.5) | 2 (1.6) | 4 (1.0) |
 |  | GAC → GTC | Asp516Val | 4 (8.5) | 1 (1.8) | 0 (0.0) | 2 (4.3) | 2 (2.9) | 3 (2.4) | 12 (3.1) |
 |  | GAC → TAC | Asp516Tyr | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (4.3) | 1 (1.5) | 2 (1.6) | 5 (1.3) |
 |  | CAC → CGC | His526Arg | 1 (2.1) | 0 (0.0) * | 1 (2.6) | 1 (2.1) | 4 (5.8) | 1 (0.8) | 8 (2.1) |
 |  | CAC → CTC | His526Leu | 1 (2.1) | 0 (0.0) | 1 (2.6) | 1 (2.1) | 3 (4.4) | 1 (0.8) | 7 (1.8) |
 |  | CAC → GAC | His526Asp | 4 (8.5) | 1 (1.8) | 0 (0.0) | 4 (8.5) | 4 (5.8) | 10 (8.1) | 23 (6.0) |
 |  | CAC → TAC | His526Tyr | 3 (6.4) | 1 (1.8) | 1 (2.6) | 5 (10.6) | 9 (13.0) | 13 (10.5) | 32 (8.4) |
 |  | TCG → TGG | Ser531Trp | 2 (4.3) | 1 (1.8) * | 0 (0.0) | 1 (2.1) * | 3 (4.4) * | 1 (0.8) * | 8 (2.1) |
 |  | TCG → TTG | Ser531Leu | 12 (25.5) | 5 (8.8) | 14 (35.9) | 25 (53.2) | 34 (49.3) | 69 (55.6) | 159 (41.5) |
 |  | CTG → CCG | Leu533Pro | 0 (0.0) | 1 (1.8) | 0 (0.0) | 0 (0.0) | 2 (2.9) | 5 (4.0) | 8 (2.1) |
 |  | CTG → CCG+ GAC → GGC | Leu511Pro + Asp516Gly | 1 (2.1) | 0 (0.0) | 0 (0.0) | 1 (2.1) | 0 (0.0) | 0 (0.0) | 2 (0.5) |
 |  | CTG → CCG + GAC → TAC | Leu511Pro + Asp516Tyr | 1 (2.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.3) |
 |  | CTG → CCG + GAC → GTC | Leu511Pro + Asp516Val | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.8) | 1 (0.3) |
 |  | CTG → CCG + CAC → TAC | Leu511Pro + His526Tyr | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (1.6) | 2 (0.5) |
 |  | CAA → CCA + GAC → GTC | Gln513Pro + Asp516Val | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.8) | 1 (0.3) |
 |  | GAC → GGC + CTG → CCG | Asp516Gly + Leu533Pro | 2 (4.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.8) | 3 (0.8) |
 | Other locus | Other mutations | Other substitutions | 6 (12.8) | 45 (79.0) * | 20 (51.3) * | 1 (2.1) | 1 (1.5) * | 1 (0.8) * | 74 (19.3) |
Total | Â | Â | Â | 47 (100.0) | 57 (100.0) | 39 (100.0) | 47 (100.0) | 69 (100.0) | 124 (100.0) | 383 (100.0) |
MDR | rpoB+ KatG | CTG → CCG+ AGC → ACC | Leu511Pro + Ser315Thr | 8 (21.6) | 0 (0.0) * | 0 (0.0) * | 0 (0.0) * | 3 (7.0) | 6 (8.1) | 17 (7.0) |
 |  | GAC → GGC + AGC → AAC | Asp516Gly + Ser315Asn | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.4) | 1 (0.4) |
 |  | GAC → GGC + AGC → ACC | Asp516Gly + Ser315Thr | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.4) | 1 (0.4) |
 |  | GAC → GTC + AGC → ACC | Asp516Val + Ser315Thr | 3 (8.1) | 0 (0.0) | 0 (0.0) | 1 (3.5) | 2 (4.7) | 1 (1.4) | 7 (2.9) |
 |  | GAC → TAC + AGC → ACC | Asp516Tyr + Ser315Thr | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (3.5) | 1 (2.3) | 1 (1.4) | 3 (1.2) |
 |  | CAC → CGC + AGC → ACC | His526Arg + Ser315Thr | 1 (2.7) | 0 (0.0) * | 1 (5.0) | 1 (3.5) | 3 (7.0) | 0 (0.0) | 6 (2.5) |
 |  | CAC → CTC + AGC → ACC | His526Leu + Ser315Thr | 1 (2.7) | 0 (0.0) | 0 (0.0) | 1 (3.5) | 0 (0.0) | 0 (0.0) | 2 (0.8) |
 |  | CAC → GAC + AGC → AAC | His526Asp + Ser315Asn | 1 (2.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.4) |
 |  | CAC → GAC + AGC → ACC | His526Asp + Ser315Thr | 3 (8.1) | 1 (2.6) | 0 (0.0) | 3 (10.3) | 3 (7.0) | 5 (6.8) | 15 (6.2) |
 |  | CAC → TAC + AGC → ACC | His526Tyr + Ser315Thr | 1 (2.7) | 0 (0.0) | 1 (5.0) | 5 (17.2) | 5 (11.6) | 7 (9.5) | 19 (7.9) |
 |  | TCG → TGG + AGC → AAC | Ser531Trp + Ser315Asn | 0 (0.0) | 0 (0.0) * | 0 (0.0) | 0 (0.0) | 1 (2.3) * | 0 (0.0) * | 1 (0.4) |
 |  | TCG → TGG + AGC → ACC | Ser531Trp + Ser315Thr | 2 (5.4) | 1 (2.6) | 0 (0.0) | 0 (0.0) | 1 (2.3) | 1 (1.4) | 5 (2.1) |
 |  | TCG → TTG + AGC → AAC | Ser531Leu + Ser315Asn | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (4.7) | 4 (5.4) | 6 (2.5) |
 |  | TCG → TTG + AGC → ACC | Ser531Leu + Ser315Thr | 8 (21.6) | 2 (5.1) | 8 (40.0) | 14 (48.3) | 18 (41.9) | 34 (46.0) | 84 (34.7) |
 |  | CTG → CCG + AGC → ACC | Leu533Pro + Ser315Thr | 0 (0.0) | 1 (2.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (4.1) | 4 (1.7) |
 | rpoB + inhA | GAC → GGC + C → T | Asp516Gly + C(−15) → T | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.3) | 0 (0.0) | 1 (0.4) |
 |  | CAC → CGC + C → T | His526Arg + C(−15) → T | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.3) | 0 (0.0) | 1 (0.4) |
 |  | TCG → TGG + C → T | Ser531Trp + C(−15) → T | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.3) | 0 (0.0) | 1 (0.4) |
 |  | TCG → TTG + C → T | Ser531Leu + C(−15) → T | 0 (0.0) | 0 (0.0) | 1 (5.0) | 2 (6.9) | 1 (2.3) | 1 (1.4) | 5 (2.1) |
 | rpoB + rpoB + KatG | CTG → CCG + GAC → GGC + AGC → ACC | Leu511Pro + Asp516Gly + Ser315Thr | 1 (2.7) | 0 (0.0) | 0 (0.0) | 1 (3.5) | 0 (0.0) | 0 (0.0) | 2 (0.8) |
 |  | CTG → CCG + GAC → GTC + AGC → ACC | Leu511Pro + Asp516Val + Ser315Thr | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.4) | 1 (0.4) |
 |  | CTG → CCG + CAC → TAC + AGC → ACC | Leu511Pro + His526Tyr + Ser315Thr | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.4) | 1 (0.4) |
 |  | CAA → CCA + GAC → GTC + AGC → ACC | Gln513Pro + Asp516Val + Ser315Thr | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.4) | 1 (0.4) |
 |  | GAC → GGC + CTG → CCG + AGC → AAC | Asp516Gly + Leu533Pro + Ser315Asn | 2 (5.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (0.8) |
 |  | GAC → GGC + CTG → CCG + AGC → ACC | Asp516Gly + Leu533Pro + Ser315Thr | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.4) | 1 (0.4) |
 | rpoB + KatG + inhA | TCG → TTG + AGC → ACC + C → T | Ser531Leu + Ser315Thr + C(−15) → T | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (4.1) | 3 (1.2) |
 | Other locus | Other mutations | Other substitutions | 6 (16.2) | 34 (87.2) * | 9 (45.0) * | 0 (0.0) * | 0 (0.0) * | 2 (2.8) * | 51 (21.1) |
 | Total |  |  | 37 (100.0) | 39 (100.0) | 20 (100.0) | 29 (100.0) | 43 (100.0) | 74 (100.0) | 242 (100.0) |