Fig. 7
Effect of HDB1258 on the composition of gut microbiota in mice with LPS-induced systemic inflammation. A Effects on α-diversity (OUT richness). B Effects on β-diversity. C Effects on the gut bacteria composition at the phylum level. D The correlation between gut microbiota (at the family and genus levels) and ratio of IL-10 to TNF-α expression in the colon. E The correlation between gut microbiota (at the family and genus levels) and ratio of IL-10 to TNF-α expression in the spleen. Mice was intraperitoneally injected with LPS (10 μg/kg/day) for 10 days. HDB1258 (LPS, vehicle; LL, 1 × 108 CFU/mouse/day and LH, 1 × 109 CFU/mouse/day) was orally gavaged daily for 14 days from the final injection of LPS. Normal control mice (NC) were treated with vehicle (saline) instead of LPS and test agents. Cytokine expression levels in the spleen were assayed using qPCR and those in the colon were using ELISA. Data values were described as mean ± SD (n = 7). #p < 0.05 vs. NC. *p < 0.05 vs. group treated with LPS alone