Fig. 6
Effect of HDB1258 on the LPS-induced colitis in mice with LPS-induced systemic inflammation. on the colon length a, myeloperoxidase (MPO) activity b, IL-1β c, IL-6 d, TNF-α e, and IL-10 expression f, ratio of IL-10 to TNF-α expression g, and NF-κB+CD11c+ cell population h. Mice was intraperitoneally injected with LPS (10 μg/kg/day) for 10 days. HDB1258 (LPS, vehicle; LL, 1 × 108 CFU/mouse/day and LH, 1 × 109 CFU/mouse/day) was orally gavaged daily for 14 days from the final injection of LPS. Normal control mice (NC) were treated with saline instead of LPS and test agents. Cytokine expression levels were assayed using ELISA kits. Data values were described as mean ± SD (n = 7). #p < 0.05 vs. NC. *p < 0.05 vs. group treated with LPS alone