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Fig. 5 | BMC Microbiology

Fig. 5

From: Lactobacillus rhamnosus HDB1258 modulates gut microbiota-mediated immune response in mice with or without lipopolysaccharide-induced systemic inflammation

Fig. 5

Effect of HDB1258 on splenic NK cell cytotoxicity, peritoneal macrophage phagocytosis, blood PGE2 level, splenic Th1 and Treg cell differentiation, splenic T-bet, Foxp3, TNF-α, and IL-10 expression in mice with LPS-induced systemic inflammation. A Effects on splenic NK cell cytotoxicity a, peritoneal macrophage phagocytosis b, and blood PGE2 level c. B Effects on the differentiation of Th1 a and Treg cells b and ratio of Th1 to Treg cells c. C Effects on the expression of T cell transcription factors T-bet a and Foxp3 b and ratio of T-bet to Foxp3 expression c. D Effects on the expression of TNF-α a and IL-10 b and ratio of TNF-α to IL-10 expression C. Mice was interaperitoneally injected with LPS (10 μg/kg/day) for 10 days. HDB1258 (LPS, vehicle; LL, 1 × 108 CFU/mouse/day and LH, 1 × 109 CFU/mouse/day) was orally gavaged daily for 14 days from the final injection of LPS. Normal control mice (NC) were treated with saline instead of LPS and test agents. Cytokine expression levels were assayed using qPCR. Data values were described as mean ± SD (n = 7). #p < 0.05 vs. NC. *p < 0.05 vs. group treated with LPS alone

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