Fig. 1
Effect of HDB1258 on the expression of proinflammatory cytokines in macrophages stimulated with or without LPS. A Effect on TNF-α a, IL-6 b, and IL-10 expression c and ratio of TNF-α to IL-10 expression d in macrophage cells. B Effect on TNF-α a, IL-6 b, and IL-10 expression c and ratio of IL-10 to TNF-α expression d in LPS-stimulated macrophage cells. Macrophage cells (1 × 106/mL) isolated from peritoneal cavity were incubated with HDB1258 (LL, 1 × 104 CFU/mL; LH, 1 × 105 CFU/mL) in the absence or presence of LPS. Normal control group (NC) was treated with saline instead of LPS. Cytokine expression levels were assayed using ELISA kits. Data values were described as mean ± SD (n = 6). #p < 0.05 vs. NC. *p < 0.05 vs. group treated with LPS alone