Fig. 6

Spearman’s rank correlation analysis between dry eye indices and gut microbiome at the genus level. a NEI score showed significant positive relation with Alistipes (r = 0.639, p < 0.001) and Bacteroides (r = 0.669, p < 0.001), and negative relation with Paraprevotella (r = − 0.623, p = 0.001). b Tear secretion showed negative relation with both Prevotella (r = − 0.439, p = 0.011) and Helicobacter (r = − 0.455, p = 0.008). c Tear secretion with body weight adjustment showed negative relation with Alistipes (r = − 0.458, p = 0.007) and Bacteroides (r = − 0.436, p = 0.011). NEI: National Eye Institute